Regulation of Male Fertility by the Opioid System

Subirán, Nerea; Casis, Luı́s; Irazusta, Jon

doi:10.2119/molmed.2010.00268

Cited by 52 publications

(39 citation statements)

References 91 publications

(113 reference statements)

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“…The immediate positive effect of met-enkephalin was completely reversed in the presence of naloxone, indicating that the effect was specifically due to the activation of opioid receptors by metenkephalin (13,15). This effect on sperm motility may be mediated by activation of DOR, since enkephalins are the preferred endogenous ligands for DOR (10). In addition, this result is consistent with the observation that the DOR antagonist naltrindole causes a decrease in sperm motility (13).…”

Section: Discussionsupporting

confidence: 85%

“…Met-enkephalin is an opioid peptide present in the male reproductive tract, mainly in testis, epididymis, and seminal plasma, suggesting that this pentapeptide may play a role in male reproduction (10). In the present work, we have shown that met-enkephalin and its precursor PENK are present in human spermatozoa and that this pentapeptide participates in the regulation of sperm motility via autocrine mechanisms.…”

Section: Discussionsupporting

confidence: 53%

“…In particular, EOPs appear to be increasingly important in sperm cell function (10). Thus, very high concentrations of some opioid peptides, such as endorphins and enkephalins, have been found in semen, in sperm cells, and in the female reproductive tract (11,12).…”

mentioning

confidence: 99%

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Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide

Subirán

Candenas

Pinto

et al. 2012

Fertility and Sterility

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 53%

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Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide

Subirán

Candenas

Pinto

et al. 2012

Fertility and Sterility

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“…The teratocarcinoma-derived growth factor 1 ( TDGF1 ) and proenkephalin ( PENK ) genes were the most DE genes observed and both have been shown to play an essential role in embryonic development, the estrous cycle, and early pregnancy, which coincide with the strong body of evidence for the role of PENK in neural tissues [37], [38]. TDGF1 and PENK were up-regulated in the POST heifers in five out of eight tissues analyzed (uterus, endometrium, hypothalamus, pituitary gland and liver).…”

Section: Resultsmentioning

confidence: 94%

Multi-Tissue Omics Analyses Reveal Molecular Regulatory Networks for Puberty in Composite Beef Cattle

et al. 2014

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Puberty is a complex physiological event by which animals mature into an adult capable of sexual reproduction. In order to enhance our understanding of the genes and regulatory pathways and networks involved in puberty, we characterized the transcriptome of five reproductive tissues (i.e. hypothalamus, pituitary gland, ovary, uterus, and endometrium) as well as tissues known to be relevant to growth and metabolism needed to achieve puberty (i.e., longissimus dorsi muscle, adipose, and liver). These tissues were collected from pre- and post-pubertal Brangus heifers (3/8 Brahman; Bos indicus x 5/8 Angus; Bos taurus) derived from a population of cattle used to identify quantitative trait loci associated with fertility traits (i.e., age of first observed corpus luteum (ACL), first service conception (FSC), and heifer pregnancy (HPG)). In order to exploit the power of complementary omics analyses, pre- and post-puberty co-expression gene networks were constructed by combining the results from genome-wide association studies (GWAS), RNA-Seq, and bovine transcription factors. Eight tissues among pre-pubertal and post-pubertal Brangus heifers revealed 1,515 differentially expressed and 943 tissue-specific genes within the 17,832 genes confirmed by RNA-Seq analysis. The hypothalamus experienced the most notable up-regulation of genes via puberty (i.e., 204 out of 275 genes). Combining the results of GWAS and RNA-Seq, we identified 25 loci containing a single nucleotide polymorphism (SNP) associated with ACL, FSC, and (or) HPG. Seventeen of these SNP were within a gene and 13 of the genes were expressed in uterus or endometrium. Multi-tissue omics analyses revealed 2,450 co-expressed genes relative to puberty. The pre-pubertal network had 372,861 connections whereas the post-pubertal network had 328,357 connections. A sub-network from this process revealed key transcriptional regulators (i.e., PITX2, FOXA1, DACH2, PROP1, SIX6, etc.). Results from these multi-tissue omics analyses improve understanding of the number of genes and their complex interactions for puberty in cattle.

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“…They are involved in the release of gonadotropins from the pituitary (Figure 2A); the function of Sertoli cells in the testis ( Figure 2B); and the function and motility of spermatozoa ( Figure 2C and D). 52 The opioid system is controlled by endogenous opioid peptides (EOPs), which exert their action through opioid receptors for which the EOPs exhibit different affinities. Within the testis, the EOPs are present in different cell types and appear to intervene in the control of spermatogenesis.…”

Section: Opioidsmentioning

confidence: 99%

An update on the potential for male contraception: emerging options

Garside¹,

Gebril²,

Alsaadi³

et al. 2013

OAJC

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The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future.

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Regulation of Male Fertility by the Opioid System

Cited by 52 publications

References 91 publications

Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide

Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide

Multi-Tissue Omics Analyses Reveal Molecular Regulatory Networks for Puberty in Composite Beef Cattle

An update on the potential for male contraception: emerging options

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