Regulation of GluA1 phosphorylation by <i>d</i>‐amphetamine and methylphenidate in the cerebellum

Cutando, Laura; Puighermanal, Emma; Castell, Laia; Tarot, Pauline; Bertaso, Federica; Bonnavion, Patricia; d’Exaerde, Alban de Kerchove; Isingrini, Elsa; Galante, Micaela; Dallérac, Glenn; Pascoli, Vincent; Lüscher, Christian; Valjent, Emmanuel

doi:10.1111/adb.12995

Cited by 3 publications

(1 citation statement)

References 62 publications

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“…Analyses of Drd2, Pvalb, Penk, Chat and Slc18a3 mRNAs expression were performed using single molecule fluorescent in situ hybridization (smFISH) (28). Brains from 3 C57BL/6 male mice were rapidly extracted and snap-frozen on dry ice and stored at -80°C until use.…”

Section: Single Molecule Fluorescent In Situ Hybridizationmentioning

confidence: 99%

Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus

Espallergues,

Boubaker-Vitre,

Mignon

et al. 2024

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The external globus pallidus (GPe) is part of the basal ganglia circuit and plays a key role in controlling the actions. Although, many evidence indicate that dopamine through its activation of D2 receptors (D2Rs) modulates the GPe neuronal activity, the precise spatiomolecular characterization of cell populations expressing D2Rs in the mouse GPe is still lacking. By combining single molecule in situ hybridization, cell type-specific imaging analyses, and electrophysiology slice recordings, we found that GPe D2R cells are neurons preferentially localized in the caudal portion of GPe. These neu- rons comprising pallido-striatal, pallido-nigral, and pallido-cortical neurons segregate into two distinct populations displaying molecular and electrophysiological features of GPe GABAergic PV/NKX2.1 and cholinergic neurons respectively. By clarifying the spatial molecular identity of GPe D2R neurons in the mouse, this work provides the basis for future studies aiming at disentangling the action of do- pamine within the GPe.

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Section: Single Molecule Fluorescent In Situ Hybridizationmentioning

confidence: 99%

Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus

Espallergues,

Boubaker-Vitre,

Mignon

et al. 2024

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Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action

Caragea,

Méndez-Couz,

Manahan-Vaughan

2023

Brain Struct Funct

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The dopaminergic (DA) system regulates both motor function, and learning and memory. The cerebellum supports motor control and the acquisition of procedural memories, including goal-directed behavior, and is subjected to DA control. Its fastigial nucleus (FN) controls and interprets body motion through space. The expression of dopamine receptors has been reported in the deep cerebellar nuclei of mice. However, the presence of dopamine D1-like (D1R) and D2-like (D2R) receptors in the rat FN has not yet been verified. In this study, we first confirmed that DA receptors are expressed in the FN of adult rats and then targeted these receptors to explore to what extent the FN modulates goal-directed behavior. Immunohistochemical assessment revealed expression of both D1R and D2R receptors in the FN, whereby the medial lateral FN exhibited higher receptor expression compared to the other FN subfields. Bilateral treatment of the FN with a D1R antagonist, prior to a goal-directed pellet-reaching task, significantly impaired task acquisition and decreased task engagement. D2R antagonism only reduced late performance post-acquisition. Once task acquisition had occurred, D1R antagonism had no effect on successful reaching, although it significantly decreased reaching speed, task engagement, and promoted errors. Motor coordination and ambulation were, however, unaffected as neither D1R nor D2R antagonism altered rotarod latencies or distance and velocity in an open field. Taken together, these results not only reveal a novel role for the FN in goal-directed skilled reaching, but also show that D1R expressed in FN regulate this process by modulating motivation for action.

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Cerebellar dopamine D2 receptors regulate social behaviors

et al. 2022

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Regulation of GluA1 phosphorylation by d‐amphetamine and methylphenidate in the cerebellum

Cited by 3 publications

References 62 publications

Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus

Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus

Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action

Cerebellar dopamine D2 receptors regulate social behaviors

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