Regulation of GFRα‐1 and GFRα‐2 mRNAs in rat brain by electroconvulsive seizure

Altered glial cell line-derived neurotrophic factor (GDNF) concentrations in the brain of patients with depressive disorder: A comparative post-mortem study

“…This stands in line with another clinical study, which examined GDNF levels in patients with mood disorder who were treated with antidepressants [94]. Our findings are further supported by studies in the animal model which have suggested that chronic treatment with several classes of antidepressants such as SSRI and TCA does not affect GDNF mRNA and protein levels in the CA1, CA3 region of the dentate gyrus and the hippocampus in rat brain [19, 36]. However, these findings in clinical populations and in the animal model stand in contrast to cell culture studies showing an influence of antidepressants on GDNF levels [36,38,105].…”

Altered glial cell line-derived neurotrophic factor (GDNF) concentrations in the brain of patients with depressive disorder: A comparative post-mortem study

“…This stands in line with another clinical study, which examined GDNF levels in patients with mood disorder who were treated with antidepressants [94]. Our findings are further supported by studies in the animal model which have suggested that chronic treatment with several classes of antidepressants such as SSRI and TCA does not affect GDNF mRNA and protein levels in the CA1, CA3 region of the dentate gyrus and the hippocampus in rat brain [19, 36]. However, these findings in clinical populations and in the animal model stand in contrast to cell culture studies showing an influence of antidepressants on GDNF levels [36,38,105].…”

Antidepressants and neuroplasticity

“…In vitro studies using the astrocytic‐derived C6 glioma culture cells showed that different classes of antidepressants increased GDNF mRNA expression and enhanced its release into the media, effects observed for unto 2 days (72). In contrast, in vivo studies using long‐term administration of several different classes of antidepressants did not show regulation of either GDNF, or its receptors (GFR‐1, GFR‐2 and c‐Ret) (73). That the results differ between in vitro and in vivo studies indicate that caution must be used when comparing different models systems.…”

Cistanche tubulosa Protects Dopaminergic Neurons through Regulation of Apoptosis and Glial Cell-Derived Neurotrophic Factor: in vivo and in vitro

“…Research has showed that there are four different types of GFRα: GFRα1, GFRα2, GFRα3 and GFRα4. GFRα1 is a high affinity receptor of GDNF (Onochie et al, 2000; Chen et al, 2001; Lindahl et al, 2001). Ret protein is a functional receptor of GDNF.…”

Altered glial cell line-derived neurotrophic factor (GDNF) concentrations in the brain of patients with depressive disorder: A comparative post-mortem study

“…This stands in line with another clinical study, which examined GDNF levels in patients with mood disorder who were treated with antidepressants [94]. Our findings are further supported by studies in the animal model which have suggested that chronic treatment with several classes of antidepressants such as SSRI and TCA does not affect GDNF mRNA and protein levels in the CA1, CA3 region of the dentate gyrus and the hippocampus in rat brain [19, 36]. However, these findings in clinical populations and in the animal model stand in contrast to cell culture studies showing an influence of antidepressants on GDNF levels [36,38,105].…”

Antidepressants and neuroplasticity

“…In vitro studies using the astrocytic‐derived C6 glioma culture cells showed that different classes of antidepressants increased GDNF mRNA expression and enhanced its release into the media, effects observed for unto 2 days (72). In contrast, in vivo studies using long‐term administration of several different classes of antidepressants did not show regulation of either GDNF, or its receptors (GFR‐1, GFR‐2 and c‐Ret) (73). That the results differ between in vitro and in vivo studies indicate that caution must be used when comparing different models systems.…”

Cistanche tubulosa Protects Dopaminergic Neurons through Regulation of Apoptosis and Glial Cell-Derived Neurotrophic Factor: in vivo and in vitro

“…Research has showed that there are four different types of GFRα: GFRα1, GFRα2, GFRα3 and GFRα4. GFRα1 is a high affinity receptor of GDNF (Onochie et al, 2000; Chen et al, 2001; Lindahl et al, 2001). Ret protein is a functional receptor of GDNF.…”

Altered glial cell line-derived neurotrophic factor (GDNF) concentrations in the brain of patients with depressive disorder: A comparative post-mortem study

“…This stands in line with another clinical study, which examined GDNF levels in patients with mood disorder who were treated with antidepressants [94]. Our findings are further supported by studies in the animal model which have suggested that chronic treatment with several classes of antidepressants such as SSRI and TCA does not affect GDNF mRNA and protein levels in the CA1, CA3 region of the dentate gyrus and the hippocampus in rat brain [19, 36]. However, these findings in clinical populations and in the animal model stand in contrast to cell culture studies showing an influence of antidepressants on GDNF levels [36,38,105].…”

Antidepressants and neuroplasticity

“…In vitro studies using the astrocytic‐derived C6 glioma culture cells showed that different classes of antidepressants increased GDNF mRNA expression and enhanced its release into the media, effects observed for unto 2 days (72). In contrast, in vivo studies using long‐term administration of several different classes of antidepressants did not show regulation of either GDNF, or its receptors (GFR‐1, GFR‐2 and c‐Ret) (73). That the results differ between in vitro and in vivo studies indicate that caution must be used when comparing different models systems.…”

Cistanche tubulosa Protects Dopaminergic Neurons through Regulation of Apoptosis and Glial Cell-Derived Neurotrophic Factor: in vivo and in vitro

“…Research has showed that there are four different types of GFRα: GFRα1, GFRα2, GFRα3 and GFRα4. GFRα1 is a high affinity receptor of GDNF (Onochie et al, 2000; Chen et al, 2001; Lindahl et al, 2001). Ret protein is a functional receptor of GDNF.…”