Regulation of Embryonic Hematopoiesis by a Cytokine-Inducible SH2 Domain Homolog in Zebrafish

Lewis, Rowena S.; Noor, Suzita Mohd; Fraser, Fiona; Sertori, Robert; Liongue, Clifford; Ward, Alister C.

doi:10.4049/jimmunol.1301376

Cited by 14 publications

(13 citation statements)

References 67 publications

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“….TTCN 3 GAA) in its promoter, and knockdown of cish.a, but not cish.b, resulted in enhanced embryonic erythropoiesis, myelopoiesis, and lymphopoiesis. This study showed conserved CIS functions for the control of hematopoiesis through STAT5 (Lewis et al 2014).…”

Section: Cis: Inhibitor Of Cytokine and T-cell Receptor (Tcr) Signalingmentioning

confidence: 64%

Negative Regulation of Cytokine Signaling in Immunity

Yoshimura

Ito

Chikuma

et al. 2017

Cold Spring Harb Perspect Biol

147

104

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Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by multiple mechanisms. These include the suppressors of cytokine signaling (SOCS) family of proteins, which represent a main negative regulation mechanism for the JAK-STAT pathway. Cytokine-inducible Src homology 2 (SH2)-containing protein (CIS), SOCS1, and SOCS3 proteins regulate cytokine signals that control the polarization of CD4 T cells and the maturation of CD8 T cells. SOCS proteins also regulate innate immune cells and are involved in tumorigenesis. This review summarizes recent progress on CIS, SOCS1, and SOCS3 in T cells and tumor immunity.

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Section: Cis: Inhibitor Of Cytokine and T-cell Receptor (Tcr) Signalingmentioning

confidence: 64%

Negative Regulation of Cytokine Signaling in Immunity

Yoshimura

Ito

Chikuma

et al. 2017

Cold Spring Harb Perspect Biol

147

104

View full text Add to dashboard Cite

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“…This was evidenced from CISH transgenic mice, which showed increased Th2 polarization proposed to be due to suppressive effects of CISH on IL-2 signaling, including STAT5 activation ( 250 ), with CISH able to bind to the IL-2 receptor β chain component, which blocks activation of the associated JAK3 ( 48 ). A similar mechanism is likely to explain the heightened embryonic lymphopoiesis observed following knockdown of the zebrafish CISH paralogue Cish.a, which also correlated with enhanced STAT5 activation ( 251 ). CISH −/− mice suffered from airway inflammation and progressively developed a pulmonary disease characterized by enhanced eosinophils within the airways and epithelial cell hyperplasia ( 51 ).…”

Section: Socs Proteins As Regulators Of Immunity and Its Perturbation In Diseasementioning

confidence: 94%

SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer

2021

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Cytokine signaling represents one of the cornerstones of the immune system, mediating the complex responses required to facilitate appropriate immune cell development and function that supports robust immunity. It is crucial that these signals be tightly regulated, with dysregulation underpinning immune defects, including excessive inflammation, as well as contributing to various immune-related malignancies. A specialized family of proteins called suppressors of cytokine signaling (SOCS) participate in negative feedback regulation of cytokine signaling, ensuring it is appropriately restrained. The eight SOCS proteins identified regulate cytokine and other signaling pathways in unique ways. SOCS1–3 and CISH are most closely involved in the regulation of immune-related signaling, influencing processes such polarization of lymphocytes and the activation of myeloid cells by controlling signaling downstream of essential cytokines such as IL-4, IL-6, and IFN-γ. SOCS protein perturbation disrupts these processes resulting in the development of inflammatory and autoimmune conditions as well as malignancies. As a consequence, SOCS proteins are garnering increased interest as a unique avenue to treat these disorders.

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“…In vitro transcription and translation of socs4a mRNA in the presence of MOs was performed as described [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Functional Analysis of Zebrafish socs4a: Impacts on the Notochord and Sensory Function

et al. 2022

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The suppressor of cytokine signaling (SOCS) proteins play important roles in cytokine and growth factor signaling, where they act principally as negative feedback regulators, particularly of the downstream signal transducer and activator of transcription (STAT) transcription factors. This critical mode of regulation impacts on both development and homeostasis. However, understanding of the function of SOCS4 remains limited. To address this, we investigated one of the zebrafish SOCS4 paralogues, socs4a, analyzing its expression and the consequences of its ablation. The socs4a gene had a dynamic expression profile during zebrafish embryogenesis, with initial ubiquitous expression becoming restricted to sensory ganglion within the developing nervous system. The knockdown of zebrafish socs4a revealed novel roles in notochord development, as well as the formation of a functional sensory system.

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Regulation of Embryonic Hematopoiesis by a Cytokine-Inducible SH2 Domain Homolog in Zebrafish

Cited by 14 publications

References 67 publications

Negative Regulation of Cytokine Signaling in Immunity

Negative Regulation of Cytokine Signaling in Immunity

SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer

Functional Analysis of Zebrafish socs4a: Impacts on the Notochord and Sensory Function

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