Biochemical Pharmacology volume 82, issue 3, P304-311 2011 DOI: 10.1016/j.bcp.2011.04.017 View full text
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Marc Le Vee, Elodie Jouan, Bruno Stieger, Valérie Lecureur, Olivier Fardel

Abstract: AbstractThe cytokine oncostatin M (OSM) is a member of the interleukin (IL)-6 family, known to down-regulate expression of drug metabolizing cytochromes P-450 in human hepatocytes. The present study was designed to determine whether OSM may also impair expression of sinusoidal and canalicular drug transporters, which constitute important determinants of drug hepatic clearance. Exposure of primary human hepatocytes to OSM down-regulated mRNA levels of major sinusoidal solute carrier (SLC) influx transporters, …

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