Regulation of Donor T Cells in the Tolerant Rats to Graft-Versus-Host Disease by FTY720 Following Small Bowel Transplantation

Successful treatment with fingolimod of graft-versus-host disease of the central nervous system

“…In line with published data, 9,10 we observed in our patient's peripheral blood an increase in the proportion of naive B cells and effector memory CD4 1 cells (Figure 2B-C). Although most studies 3,[11][12][13] emphasized inhibition of lymphocyte egress as the main mechanism responsible for the anti-GVHD effects of fingolimod, Taylor et al reported contrasting effects of the drug in a murine model of acute GVHD. 14 In this study, fingolimod did not uniformly trap effector T cells in all secondary lymphoid organs.…”

Graft-vs-host disease after small bowel transplantation in children

“…Pentostatin is a nucleoside analog acting as a potent inhibitor of adenosine deaminase that has been also proposed as an alternative for acute refractory GVHD, but the optimal dose has not been established [23]. New perspectives on the understanding of GVHD directed to design better therapies in steroid-refractory cases are emerging in the experimental setting [30][31][32][33].…”

Difficulties, guidelines and review of developing an acute rejection model after rat intestinal transplantation

“…It was difficult to determine which was the best strain to use to establish a useful AR model and the ideal moment to determine the typical histological features [67][68][69][70][71][72]. We initially used Wistar rats as recipients based on previous publications from our center (not directly related to rejection) [17,[19][20][21].…”