2001
DOI: 10.1080/152165401317316545
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Abstract: SummaryCytochrome c oxidase, which catalyzes an irreversible step of the respiratory chain, is one of the rate-controlling steps of oxidative phosphorylation on isolated mitochondria. The rate of electron transfer through the complex is primarily controlled by the associated thermodynamic forces, i.e., the span in redox potential between oxygen and cytochrome c and the protonmotive force. However, the electron ux also depends on the various kinetic effectors, including adenylic nucleotides. Although the number… Show more

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Cited by 24 publications
(136 citation statements)
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References 78 publications
(136 reference statements)
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“…3). Regarding subunit VIIc, it is entirely possible that neither Utricularia nor any other green plant possesses this protein, which is nonessential in yeast (37,38).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…3). Regarding subunit VIIc, it is entirely possible that neither Utricularia nor any other green plant possesses this protein, which is nonessential in yeast (37,38).…”
Section: Resultsmentioning
confidence: 99%
“…17), of which VIIa moreover occurs in tissue-specific forms (16). Extensive studies with yeast have shown that subunit VIIa (corresponding to VII in yeast) is essential for assembly of the COX holoenzyme, and that subunit VIIc (corresponding to VIII in yeast) is not necessary but modulates COX catalytic activity (37,38). Leu-113 and Ala-114 of the bovine enzyme lie near the apex of a ''tripod'' formed by the C-terminal tips of helix 3 of COX I and those of VIIa and VIIc, not far from where the electron donor to COX, cytochrome c, is known to bind (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…[40][41][42] Both COX4, a regulatory subunit, and COX1, a catalytic subunit, are key proteins important in the regulation of CCO activity. The COX4 has been identified as an ATPbinding subunit, 43,44 and COX5b provides a binding site for protein kinase A. 45 The complex regulation of CCO activity arises in part from the product of the bigenomic contribution of nuclear and mitochondrial DNA, which encodes the protein subunits of CCO 41 and their assembly within the inner mitochondrial membrane.…”
Section: Discussionmentioning
confidence: 99%
“…Hypoxia decreases the V max of the mitochondrial electron transport chain oxygen-dependent cytochrome oxidase, disrupting the flow of electrons and inducing ROS leakage at Complexes I and III [10, 38, 39]. PKA phosphorylation of complexes I, IV and V of the mitochondrial electron transport chain may contribute to its deleterious effect [4, 17-20, 23-25]. In mouse fibroblasts, PKA phosphorylation of the 18 kD subunit of complex I increases its activity [18].…”
Section: Discussionmentioning
confidence: 99%
“…However, activation of PKA has also been shown to be neuroprotective in a variety of neuronal injury models [22]. PKA phosphorylates and regulates mitochondrial chain enzymes [4, 17-20, 23-25] and could potentially increase leakage of electrons and superoxide formation, and decrease ATP production. Consequently, the PKA pathway may play an important role in the regulation of metabolic pathways and energy production, critical to hypoxic survival.…”
Section: Introductionmentioning
confidence: 99%