Regulation of Cortical Functions by the Central Noradrenergic System: Emerging Properties from an Old Friend

Atzori, Marco; Salgado, Humberto; Tseng, Kuei‐Yuan

doi:10.1007/978-0-387-72256-6_13

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Prefrontal Cortex and Basal Ganglia Circuits2

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2009

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“…Excitation is modulated by inhibitory inputs mainly exerted by local GABAergic interneurons. These neuronal groups exert an important modulatory role of the excitatory and inhibitory currents in PFC neurons (11)(12)(13)(14)(15)(16). Among them, large perysomatic, parvalbumin-containing neurons such as the chandelier and baskets cells, play a major role in controlling excitatory pyramdial outputs by targeting GABA A receptors located in the cell bodies and initial segments of pyramidal axons (10).…”

Section: Prefrontal Cortex and Basal Ganglia Circuitsmentioning

confidence: 99%

“…Likewise, PFC neurons receive a dense innervation from the brainstem monoaminergic nuclei (dorsal and median raphe nuclei, locus coeruleus and ventral tegmental area, which employ 5-HT, NA and DA as main neurotransmitters, respectively). These neuronal groups exert an important modulatory role of the excitatory and inhibitory currents in PFC neurons (11)(12)(13)(14)(15)(16).…”

Section: Prefrontal Cortex and Basal Ganglia Circuitsmentioning

confidence: 99%

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