2000
DOI: 10.1038/sj.onc.1203878
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Regulation of cell death by the Abl tyrosine kinase

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Cited by 259 publications
(202 citation statements)
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“…Physiological functions dependent on c-Abl remain largely elusive. Certain insights have been derived from the findings that c-Abl shuttles between the nucleus and the cytoplasm (Taagepera et al, 1998;Wang, 2000). In contrast, oncogenic forms of Abl, including v-Abl and Bcr-Abl, localize exclusively in the cytoplasm and induce cellular transformation by promoting proliferation and inhibiting apoptotic cell death (Wetzler et al, 1993;Wang, 2000;Pendergast, 2002).…”
Section: Introductionmentioning
confidence: 99%
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“…Physiological functions dependent on c-Abl remain largely elusive. Certain insights have been derived from the findings that c-Abl shuttles between the nucleus and the cytoplasm (Taagepera et al, 1998;Wang, 2000). In contrast, oncogenic forms of Abl, including v-Abl and Bcr-Abl, localize exclusively in the cytoplasm and induce cellular transformation by promoting proliferation and inhibiting apoptotic cell death (Wetzler et al, 1993;Wang, 2000;Pendergast, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…In this regard, recent studies have suggested that cytoplasmic c-Abl confers cell proliferation and survival (Zhu and Wang, 2004). By marked contrast, activation of nuclear c-Abl by many sources of DNA damage is associated with inhibition of cell growth and induction of apoptosis (Kharbanda et al, 1998;Wang, 2000;Yoshida, 2008). These findings indicate that the intracellular localization of c-Abl is important in dictating either survival or apoptotic responses.…”
Section: Introductionmentioning
confidence: 99%
“…The c-Abl protein is located in both the nucleus and the cytoplasm. In the nucleus, c-Abl protein is known to be activated in response to DNA damage and contributes to apoptosis (Wang, 2000). Cytoplasmic c-Abl is associated with growth factor receptor signaling that can affect cell mobility and cell adhesion (Taagepera et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…It has been shown that activation of c-Abl by many sources of DNA damage is associated with inhibition of cell growth and induction of apoptosis Wang, 2000). Therefore, we examined Influence of imatinib on mutation frequencies in Bcr-Ablpositive and Bcr-Abl-negative cells.…”
Section: Introductionmentioning
confidence: 99%