2017
DOI: 10.1111/jpi.12423
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Abstract: Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions. We show here that tryptophan metabolism in the pineal gland favors bone mass accrual through production of melatonin, a pineal‐derived neurohormone. Pineal gland‐specific deletion of Tph1, the enzyme that catalyzes the first step in the melatonin biosynthesis lead to a decrease in melatonin levels and a low bone mass due to an … Show more

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Cited by 93 publications
(90 citation statements)
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“…For instance, Sharan et al. reported that melatonin at concentrations of 10 or 100 mg/kg body weight increased osteoblast numbers and bone formation. Similarly, Han et al.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…For instance, Sharan et al. reported that melatonin at concentrations of 10 or 100 mg/kg body weight increased osteoblast numbers and bone formation. Similarly, Han et al.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have shown that melatonin affects osteoblasts at physiological concentrations while affecting osteoclasts at pharmacological concentrations. For instance, Sharan et al [21] reported that melatonin at concentrations of 10 or 100 mg/kg body weight increased osteoblast numbers and bone formation. Similarly, Han et al [22] showed that melatonin, at physiological dose of 1 lM, stimulates osteoblast differentiation in C2C12 cells by Osterix activation and by increasing the expression of alkaline phosphatase (ALP), bone sialoprotein (BSP), and OCN genes.…”
Section: Circulating Osteocalcin Is Reduced In Eae Mice and Ms Patientsmentioning
confidence: 99%
“…In vitro assays of osteoblast cultures from the MT2 −/− mice have an intrinsic defect in their proliferation, differentiation, and mineralization abilities of osteoblasts compared to their wild type (WT) counterparts, and the mutant cells do not respond to melatonin. Moreover, daily oral administration of melatonin increases bone accrual and reduces ovariectomy‐induced structural and functional degeneration of bone specifically by promoting bone formation …”
Section: Mechanisms Underlying Melatonin's Action On Osteoporosismentioning
confidence: 99%
“…Pineal gland‐specific deletion of Tph1 may lead to a drop in melatonin levels and low bone mass due to an isolated decrease in bone formation. Skeletal analysis of MT2‐deficient mice shows low bone mass . In ovariectomized female Wistar rats, reduced levels of melatonin correlate with decreased bone mass, concomitant with augmented levels of ALP and PICP, and decreased levels of cross‐linked carboxyterminal telopeptide of type I collagen (ICTP), hydroxyproline, and total calcium .…”
Section: Melatonin Acts As a Protective Agent Against Osteoporosismentioning
confidence: 99%
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