Regulation of Antibody Responses via Antibodies, Complement, and Fc Receptors

Heyman, Birgitta

doi:10.1146/annurev.immunol.18.1.709

Cited by 309 publications

(292 citation statements)

References 164 publications

Supporting

Mentioning

279

Contrasting

Unclassified

Order By: Relevance

“…This is because it is well known that the activated capacities of IgG-mediated effector function through interaction with Fc Rs and activation of the complement system are differ with IgG subclass. 21) As shown in Fig. 1B, the -D-glucan AP-FBG was largely reactive to the IgG2 subclass.…”

Section: Resultsmentioning

confidence: 77%

Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan fromAureobasidium pullulansto Antibodies in Human Sera

Tada

Tanioka²,

Ishibashi

et al. 2009

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

We recently determined the structure of a unique type of 1,3--D-glucan obtained from Aureobasidium pullulans (AP-FBG) and found that it reacted with the antibodies in human sera. The reactivity of AP-FBG to the antibodies was stronger than that of 1,3--D-glucan obtained Grifola frondosa (GRN) but weaker than that of 1,3--D-glucan from Candida albicans (CSBG). Here, we demonstrated that AP-FBG reacted to IgG antibodies, especially those of the subclasses IgG2, IgG1, and IgG3, in human sera. Moreover, the results of competitive enzyme-linked immunosorbent assays (ELISAs) using various glucan competitors showed that these IgGs recognized branched chains at position 6. This is the first study to report that the branched chains at position 6 of -D-glucan strongly contribute to its recognition by antibodies in human sera. This high reactivity of AP-FBG to human IgG could be advantageous for the use of this glucan in medicine, e.g., as an immunostimulatory agent.

show abstract

Section: Resultsmentioning

confidence: 77%

Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan fromAureobasidium pullulansto Antibodies in Human Sera

Tada

Tanioka²,

Ishibashi

et al. 2009

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

show abstract

“…Another ITIM-containing receptor that has been extensively studied in the past is Fcγ receptor IIb (FcγRIIb), which gets co-engaged if the BCR recognizes antigen that is already bound by IgG [13]. The phosphorylated FcγRIIb ITIM recruits the SH2 domain-containing inositol 5-phosphatase (SHIP) which hydrolyzes PIP3 and hence destabilizes the plasma membrane localization of Ca 2+ -mobilizing enzymes [14,15].…”

Section: Introductionmentioning

confidence: 99%

Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells

Neumann

Oellerich

Heine

et al. 2011

Cellular Signalling

View full text Add to dashboard Cite

B cells require signals transduced by the B cell antigen receptor (BCR) to provide humoral adaptive immunity. These signals are modulated by co-receptors like the Fcγ receptor IIb (FcγRIIb) that prevents activation of B cells after co-ligation with the BCR. Positive and negative effectors need to be precisely organized into signaling complexes, which requires adapter proteins like the growth factor receptor-bound protein 2 (Grb2). Here, we address the question how Grb2-mediated signal integration is affected by FcγRIIb. Our data reveal that concomitant engagement of BCR and FcγRIIb leads to markedly increased Grb2-mediated formation of ternary protein complexes comprising downstream of kinase-3 (Dok-3), Grb2, and the SH2 domaincontaining inositol phosphatase (SHIP). Consistently, we found Grb2 to be required for full FcγRIIb-mediated negative regulation. To investigate how FcγRIIb influences the entire Grb2 interactions, we utilized quantitative mass spectrometry to make a differential interactome analysis. This approach revealed a shift of Grb2 interactions towards negative regulators like Dok-3, SHIP and SHP-2 and reduced binding to other proteins like CD19. Hence, we provide evidence that Grb2-mediated signal integration is a dynamic process that is important for the crosstalk between the BCR and its co-receptor FcγRIIb.

show abstract

“…In addition, FcγR expression has been demonstrated on dendritic cells and non-hematopoietic tissues such as endothelial and neuronal cells. Depending on the cell type, cross-linking of these receptors results in a variety of effector functions including antibody-dependent cell-mediated cytotoxicity, phagocytosis, release of pro-inflammatory mediators, or IgG-mediated feedback inhibition of B cells [18,22]. The family of murine and human FcγRs consists of several members that can be distinguished by two different means.…”

Section: Introductionmentioning

confidence: 99%

The role of Fcγ receptors in murine autoimmune thrombocytopenia

et al. 2010

View full text Add to dashboard Cite

International audienceImmune thrombocytopenia (ITP) can become a life-threatening condition that requires immediate medical attention. The loss in platelet numbers during ITP can be induced by a variety of triggers. Anti-platelet antibodies of several isotypes and subclasses are a major cause for ITP and are a hallmark of many complex autoimmune diseases such as systemic lupus erythematosus. Mouse models have been important to understand the effector pathways involved in antibody-mediated platelet depletion. Therapeutic interventions based on these results have been proven successful in treating human ITP, thus validating the use of these model systems. One major problem that remains to be answered is which cell populations are crucial for platelet removal. Targeting these cells directly might be a novel therapeutic strategy and will also be important to understand the underlying biological mechanisms

show abstract

Regulation of Antibody Responses via Antibodies, Complement, and Fc Receptors

Cited by 309 publications

References 164 publications

Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan fromAureobasidium pullulansto Antibodies in Human Sera

Involvement of Branched Units at Position 6 in the Reactivity of a Unique Variety of β-D-Glucan fromAureobasidium pullulansto Antibodies in Human Sera

Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells

The role of Fcγ receptors in murine autoimmune thrombocytopenia

Contact Info

Product

Resources

About