Regulating Acidosis and Relieving Hypoxia by Platelet Membrane-Coated Nanoparticle for Enhancing Tumor Chemotherapy

Luo, Xingyu; Cao, Jian; Yu, Jie; Dai, Dongqing; Jiang, Wei; Feng, Yahui; Hu, Yong

doi:10.3389/fbioe.2022.885105

Cited by 10 publications

(10 citation statements)

References 35 publications

(35 reference statements)

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“…On the other hand, due to the severe hypoxia in TME and the fact that the LOX-related reaction is an oxygen-demanding process, researchers loaded haemoglobin (Hb) into ZIF-8 to deliver oxygen to alleviate the hypoxia in tumour tissues and to enhance the catalytic activity of LOX. 75 ZIF-8, a typical MOF, has been widely used in drug delivery for tumour therapy due to its excellent drug-carrying capacity and acid-sensitive properties. [85][86][87][88] However, the low stability of ZIF-8 in water and potential cytotoxicity limit its application.…”

Section: Zeolitic Imidazolate Framework (Zifs)mentioning

confidence: 99%

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Recent progress in lactate oxidase-based drug delivery systems for enhanced cancer therapy

Li,

Yue,

Feng

et al. 2024

Nanoscale

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Section: Zeolitic Imidazolate Framework (Zifs)mentioning

confidence: 99%

“…72 In recent years, a number of LOX delivery applications have used a variety of MOF materials. 34,[73][74][75][76] Table 2 summarises the LOXbased organic-inorganic hybrid nanocomposites used for tumour therapy.…”

Section: Lox-based Organic-inorganic Hybrid Nanocarriers For Tumour T...mentioning

confidence: 99%

Recent progress in lactate oxidase-based drug delivery systems for enhanced cancer therapy

Li,

Yue,

Feng

et al. 2024

Nanoscale

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“…For tumor acidosis and hypoxia localization, Luo et al utilized ZIF‐8 to develop Hb‐LOx‐DOX‐ZIF8@platelet membrane nanoparticles. [ 49 ] LOx sufficiently depleted intratumoral lactate and effectively amplified oxidative stress to make tumors more sensitive to doxorubicin (DOX)‐induced chemotherapy. Meanwhile, hemoglobin (Hb) transported O 2 , relieving hypoxia and enhancing the catalytic activity of LOx.…”

Section: Lox‐instructed Cancer Therapymentioning

confidence: 99%

Lactate‐Oxidase‐Instructed Cancer Diagnosis and Therapy

et al. 2023

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Lactate oxidase (LOx) has attracted extensive interest in cancer diagnosis and therapy in recent years owing to its specific catalysis on l‐lactate; its catalytic process consumes oxygen (O2) and generates a large amount of hydrogen peroxide (H2O2) and pyruvate. Given high levels of lactate in tumor tissues and its tight correlation with tumor growth, metastasis, and recurrence, LOx‐based biosensors including H2O2‐based, O2‐based, pH‐sensitive, and electrochemical have been designed for cancer diagnosis, and various LOx‐based cancer therapy strategies including lactate‐depletion‐based metabolic cancer therapy/immunotherapy, hypoxia‐activated chemotherapy, H2O2‐based chemodynamic therapy, and multimodal synergistic cancer therapy have also been developed. In this review, the lactate‐specific catalytic properties of LOx are introduced, and the recent advances on LOx‐instructed cancer diagnostic or therapeutic platforms and corresponding biological applications are summarized. Additionally, the challenges and potential of LOx‐based nanomedicines are highlighted.

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“…[21,25,27,32,41,57,59,113,161] For example, Luo et al constructed Hb-LOX-DOX-ZIF8@platelet membrane nanosystem (HLDZ@PM NPs) using nano-ZIF-8 as the carrier. [162] LOX adequately depleted intratumoral lactate, making tumor cells more sensitive to DOX-induced chemotherapy.…”

Section: Combining Lactate Metabolic Regulation With Chemotherapymentioning

confidence: 99%

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

Cheng,

Shi,

et al. 2023

Advanced Science

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Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even under oxygen‐sufficient conditions. This metabolic alteration not only favors tumor cell progression and metastasis but also increases lactate accumulation in solid tumors. In addition to serving as a byproduct of glycolytic tumor cells, lactate also plays a central role in the construction of acidic and immunosuppressive tumor microenvironment, resulting in therapeutic tolerance. Recently, targeted drug delivery and inherent therapeutic properties of nanomaterials have attracted great attention, and research on modulating lactate metabolism based on nanomaterials to enhance antitumor therapy has exploded. In this review, the advanced tumor therapy strategies based on nanomaterials that interfere with lactate metabolism are discussed, including inhibiting lactate anabolism, promoting lactate catabolism, and disrupting the “lactate shuttle”. Furthermore, recent advances in combining lactate metabolism modulation with other therapies, including chemotherapy, immunotherapy, photothermal therapy, and reactive oxygen species‐related therapies, etc., which have achieved cooperatively enhanced therapeutic outcomes, are summarized. Finally, foreseeable challenges and prospective developments are also reviewed for the future development of this field.

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Regulating Acidosis and Relieving Hypoxia by Platelet Membrane-Coated Nanoparticle for Enhancing Tumor Chemotherapy

Cited by 10 publications

References 35 publications

Recent progress in lactate oxidase-based drug delivery systems for enhanced cancer therapy

Recent progress in lactate oxidase-based drug delivery systems for enhanced cancer therapy

Lactate‐Oxidase‐Instructed Cancer Diagnosis and Therapy

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

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