2013
DOI: 10.1371/journal.pone.0066996
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Abstract: Regular exercise has an antidepressant effect in human subjects. Studies using animals have suggested that the antidepressant effect of exercise is attributable to an increase of brain 5-hydroxytryptamine (5-HT); however, the precise mechanism underlying the antidepressant action via exercise is unclear. In contrast, the effect of 5-HT on antidepressant activity has not been clarified, in part because the therapeutic response to antidepressant drugs has a time lag in spite of the rapid increase of brain 5-HT u… Show more

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Cited by 23 publications
(14 citation statements)
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References 44 publications
(65 reference statements)
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“…In the present study, the weights of body and skeletal muscle of mice fed the Trp-deficient diet declined, even though the volumes of food eaten by the mice in the two groups were the same. The time course of the body weight change was similar to that described in an earlier publication [26], in which the authors suggested that a reduction in body motion, caused by a change in serotonin level, led to weight loss. Trp is one of the essential amino acids, which can be gained only from diet.…”
Section: Discussionsupporting
confidence: 82%
“…In the present study, the weights of body and skeletal muscle of mice fed the Trp-deficient diet declined, even though the volumes of food eaten by the mice in the two groups were the same. The time course of the body weight change was similar to that described in an earlier publication [26], in which the authors suggested that a reduction in body motion, caused by a change in serotonin level, led to weight loss. Trp is one of the essential amino acids, which can be gained only from diet.…”
Section: Discussionsupporting
confidence: 82%
“…McNeil et al (1991) found that physical exercise had a broader effect in reducing depressive symptoms in the moderately depressed elderly compared with control conditions, at least in the short term. Also, some studies confirmed the improvement effect of exercise on the depression model rats (Zheng et al, 2006;Lee et al, 2013). Although the clinical trials about the effect of exercise on the treatment of major depression are still controversial (Hoffman et al, 2011), there is no doubt that exercise can achieve the same therapeutic effect of depression as medication on mild to moderate depression (Poquet and Maher, 2015).…”
Section: Discussionmentioning
confidence: 96%
“…Since physical exercise may improve oxidative status and memory (Lee et al, 2013; Liu and Zhou, 2012; Patki et al, 2014; Yau et al, 2015) and studies show that CVS induces oxidative stress and impairs Na + , K + ‐ATPase and memory (De Vasconcellos et al, 2005; Della et al, 2012; Gamaro et al, 2003; Patki et al, 2014; RĂ©us et al, 2015; Tagliari et al, 2011a, 2011b, 2010b), and that antioxidants prevent energy metabolism and memory deficits caused by CVS (Tagliari et al, 2011b, 2010b), in the present study we decided to test the protective effect of physical exercise on behavioral and biochemical changes caused by CVS.…”
Section: Discussionmentioning
confidence: 99%
“…Physical exercise improves quality of life, and appears to possess, when practiced in moderation, positive action in modulating oxidative stress, and inflammatory parameters; besides, it may protect mitochondrial dysfunction and induce neurogenesis in brain structures. It also may improve the function of some other organs and tissues affected by several diseases (Bozi et al, 2016;Gomez-Cabrera et al, 2008;Lee et al, 2013;Liu and Zhou, 2012;Patki et al, 2014;Yau et al, 2015).…”
Section: Introductionmentioning
confidence: 99%