Regulação Gênica Da via Ampk Pelo Exercício Físico: Revisão Sistemática E Análise in Silico

Pacheco, Christina; Santos, Luiz Henrique Pontes dos; Alves, Juliana Osório; Queiroz, Adriano Nogueira de; Soares, Paula Matias; Ceccatto, Vânia Marilande

doi:10.1590/1517-869220172304169935

Cited by 4 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the intervention and control groups, hydrotherapy favored adequate maternal metabolic and cardiovascular adaptation to pregnancy [46]. Among other benefits, physical exercise increases the body's consumption of glucose causing negative regulation of the genes encoded in the MO25 protein and positive regulation of the AMPK encoding genes that activate the transducer of regulatory protein CREB 2 (TORC2) which has the function of controlling protein activities and inhibiting liver conversions of "aglicanos" compounds (pyruvate), reducing gluconeogenesis [47].…”

Section: Obstetric Therapies With Oral Antidiabetic Metformin Hydrochmentioning

confidence: 99%

Physical exercise and metformin in the prevention of pre-eclampsia: systematic review

2020

View full text Add to dashboard Cite

Introduction: Pre-eclampsia is a disorder that may occur during pregnancy but is still unknown and / or multifactorial causes. Objective: To verify whether physical exercise and metformin may be helpful in preventing preeclampsia. Method: This is a systematic review of the literature in PubMed / MEDLINE, Web of Science, Scopus, LILACS and Cochrane. This review followed the critiques of the PRISMA checklist. Bias assessment was used for the Cochrane Handbook for Systematical Reviews of Interventions (Version 5.1.0) for clinical trials and the Downs and Black scale for cohort and case-control studies. Results: 17 studies were within the established criteria. The subjects evaluated were: pre-eclampsia, cardiovascular metabolic factors, physiotherapeutic therapies and the effects of physical exercise and metformin on the circulatory system. Conclusion: There is a need for adapted techniques and new protocols according to the contingencies and complications of pregnancy. During pregnancy, it is suggested a greater interdisciplinarity of knowledge among professionals and that the therapy receives adjustments against the metabolic alterations of the reproductive system. In order to prevent preeclampsia, the study suggests a program of individual exercises that include greater assistance, verification and / or comprehension of possible changes and their limits during pregnancy. As well as, the adjuvant use of metformin of 1000 mg/d in the initial phase, with the purpose of maintaining the effects of the drug due to renal clearance during pregnancy, until reaching a maximum of 1500 mg/d, to avoid side effects of the drug.

show abstract

Section: Obstetric Therapies With Oral Antidiabetic Metformin Hydrochmentioning

confidence: 99%

Physical exercise and metformin in the prevention of pre-eclampsia: systematic review

2020

View full text Add to dashboard Cite

show abstract

“…Physical activity can activate AMPK and reduce conversions of "aglicanos" compounds. 19 A recent study showed that pregnant women who followed the guidelines on physical activities and diet composition altered gene expression that relates to fatty acid transport. Active women had lower expression of fatty acid transport protein 4 (FATP4).…”

Section: Physical Activity and Gene Regulation Programsmentioning

confidence: 99%

“…(mTOR), which regulates energy in the intracellular space. 19 Physical activity activates AMPK in several ways and in different routes. In order to reduce gluconeogenesis, physical exercise increases the consumption of glucose by the organism and, subsequently, there is a negative regulation of the genes encoded in the MO25 protein.…”

Section: Authors' Contributionmentioning

confidence: 99%

“…In order to reduce gluconeogenesis, physical exercise increases the consumption of glucose by the organism and, subsequently, there is a negative regulation of the genes encoded in the MO25 protein. 19 When the MO25 protein is suppressed, there is a positive regulation of the AMPK coding genes that activates the regulatory CREB protein 2 (TORC2) transducer, which has the function of controlling protein activities and inhibiting liver conversions of "aglicanos" compounds (pyruvate), reducing gluconeogenesis. 19…”

Section: Authors' Contributionmentioning

confidence: 99%

See 1 more Smart Citation

Physical exercise and metformin in gestational obesity and prevention on gestational diabetes mellitus: a systematic review

Nascimento

Fleig

Souza

et al. 2020

Rev. Bras. Saude Mater. Infant.

View full text Add to dashboard Cite

Objectives: identify the action of metformin and physical activities to reduce weight gain and prevent mellitus diabetes in obese pregnant women. Methods: the electronic search was performed in PubMed / MEDLINE, LILACS, Web of Science, Scopus and Cochrane library databases between 2008 and 2018. The selection took place between April and July 2018, through the descriptors "pregnancy, obesity, metformin, treatment, exercise". A protocol was programmed and consecutively a selective research on the inclusion / exclusion phase. The "PICO" strategy was used. Population: obese pregnant women. Intervention: physical exercises and metformin. Control: The main indicator established was therapeutic outcomes with physical activity and metformin. Outcome of interest: body weight control. Results: by selecting the database, 3,983 articles were identified on the topic of interest. After selecting and eligibility, only 16 scientific studies were selected, of which 81.25% were clinical trials related to diet programs, physical activity, metformin use and possible outcomes, 18.75% were prospective cohort on causes of obesity in gestation and its association with gestational mellitus diabetes and preventive therapies. The study pointed out the possibility of adapting physical therapy programs with the correct metformin dosage for a greater control in gestational weight gain. However, there is a need for greater awareness and changes in habits for obese woman during the gestational period. Conclusions: the drug presents similarity to physical activity by activating AMPK and may be added to treatments that propose changes in pregnant women’s lifestyle to reduce weight gain and prevent gestational diabetes mellitus with a better understanding of the optimal dosage. Thus, the study suggests the use of metformin is not only for the prevention and the intercurrence of gestational diabetes mellitus, but a strictly careful investigation allowing its use to non-diabetic obese pregnant women.

show abstract

“…Conclusion: Acute isometric exercise with a handgrip at 50% of CVM was able to promote a significant reduction in capillary glycemia levels in elderly women with DM2, exposed to the exercise protocol. independentemente da modalidade do exercício 12,13 .…”

Section: Introductionmentioning

confidence: 99%

[Id 55108] Respostas Glicêmicas Após Exercício Isométrico Com Handgrip Em Idosas Portadoras De Diabetes Mellitus Tipo 2: Ensaio Clínico Randomizado

Rêgo¹,

Sabino²,

Barbosa³

et al. 2021

RBCS

View full text Add to dashboard Cite

Objetivo: Avaliar o efeito de uma única sessão de exercício isométrico com handgrip sobre as respostas glicêmicas de idosas portadoras diabetes mellitus tipo 2 (DM2). Metodologia: Trata-se de um ensaio clínico randomizado. A amostra foi composta por 14 idosas portadoras de DM2, fisicamente ativas, com idade de 66,29 ± 7,3 anos. As participantes foram divididas aleatoriamente em dois grupos, o grupo controle (GC n = 7) e o grupo intervenção (GI n = 7). Com um dinamômetro de preensão manual, a força de contração voluntária máxima (CVM) foi medida em ambas as mãos. Para a intensidade da sessão experimental, foi utilizada 50% da carga de CVM encontrada no teste. A glicemia capilar foi coletada nos tempos pré, imediatamente após (IA), 30 e 60 minutos após a intervenção. Resultados: Não ocorreu diferença estatística entre as interações (grupo vs. tempo) e entre os grupos. Apenas o GI apresentou diferença significativa em relação ao tempo (pré = 165.5 ± 39.4 mg/dL vs. IA= 139.2±25.9 mg/dL; p = 0,026; pré = 165.5 ± 39.4 mg/dL vs. pós 30 = 126.2±17.1 mg/dL; p = 0,012; pré = 165.5 ± 39.4 mg/dL vs. pós 60 = 120.8 ±20.2 mg/dL; p = 0,009) quando comparado como o GC. Conclusão: O exercício isométrico agudo com handgrip a 50% da CVM foi capaz de promover uma redução significativa nos níveis de glicemia capilar em idosas com DM2, expostas ao protocolo de exercício.

show abstract

Regulação Gênica Da via Ampk Pelo Exercício Físico: Revisão Sistemática E Análise in Silico

Cited by 4 publications

References 40 publications

Physical exercise and metformin in the prevention of pre-eclampsia: systematic review

Physical exercise and metformin in the prevention of pre-eclampsia: systematic review

Physical exercise and metformin in gestational obesity and prevention on gestational diabetes mellitus: a systematic review

[Id 55108] Respostas Glicêmicas Após Exercício Isométrico Com Handgrip Em Idosas Portadoras De Diabetes Mellitus Tipo 2: Ensaio Clínico Randomizado

Contact Info

Product

Resources

About