Regression of multiple hepatocellular adenomas after cessation of oral contraceptive pills : a case report and review of the current literature

Abstract

Hepatocellular adenoma (HCA) is an uncommon benign liver neoplasm usually solitary and identified incidentally on imaging. We report a case of a 50-year old female who was diagnosed with multiple hepatic adenomas of the inflammatory subtype. After discontinuation of oral contraception a decrease of both the number and size of the liver lesions was seen on magnetic resonance imaging (MRI) without the need of further intervention. The major challenge in the clinical management of patients with multiple HCAs resides in the risk assessment for future complications. In the case of multiple HCAs subtype seemed to be more relevant than the actual number of lesions. Because little is known about the natural evolution in patients with multiple HCAs, we performed a review of the current literature with focus on the different subtypes and their clinical relevance.

Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice

“…It is rare in children, men, and those aged >65 years. In recent years, cases of HCA have also arisen due to obesity and metabolic syndrome, and it has been predicted that the number of such patients may increase in the future [ 5 , 6 ]. The diagnosis of HCA requires differentiation from focal nodular hyperplasia (FNH), which is a non-neoplastic lesion, as well as from HCC, which is often difficult to diagnose based on the histologic findings alone.…”