Regiospecific Cyclization of 4‐Alkoxyvinyl Trifluoro[chloro]methyl Ketones with 6‐Trifluoro[chloro]methyl‐2‐hydrazine Pyrimidines. A Convenient Method to Obtain Trifluoro[chloro]methylated 2‐(5‐Hydroxy‐5‐trifluoro [chloro]methyl‐4,5‐dihydro‐1H‐pyrazol‐l‐yl)pyrimidines.

Abstract

Obtain Trifluoro[chloro]methylated 2-(5-Hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-pyrazol-l-yl)pyrimidines. -The synthesis of title compounds such as (V) (12 examples) is achieved by straightforward synthesis of hetaryl hydrazines followed by regioselective cyclocondensation with halogenated keto-substituted enol ethers. -(ZANATTA*, N.; FLORES, D. C.; MADRUGA, C. C.; FAORO, D.; FLORES, A. F. C.; BONACORSO, H. G.; MARTINS, M. A. P.; Synthesis 2003, 6, 894-898; Dep. Quim., Univ. Fed. Santa Maria, 97105 Santa Maria, Brazil; Eng.) -Mais 34-136