Regioselective, One‐Pot, Three‐Component Synthesis of 1,3,4‐ and 1,3,5‐Triarylpyrazoles from 1‐ and 2‐Aryl‐1‐alkenyl Sulfones

Regioselective, One-Pot, Three-Component Synthesis of 1,3,4-and 1,3,5-Triarylpyrazoles from 1-and 2-Aryl-1-alkenyl Sulfones. -Aldehydes and hydrazines are used together with the title sulfones which control the regioselectivity of the product formation. DDQ is found to be an effective oxidant and the addition of the strong acid TFA is not required. Thus, products like (VIII), (X), (XII), and (XIV) bearing aryl moieties with acid-labile functionality can be synthesized in one pot. -(FUSE*, S.; SUGIYAMA, H.; KOBAYASHI, D.; IIJIMA, Y.; MATSUMURA, K.; TANAKA, H.; TAKAHASHI, T.; Eur. J. Org. Chem. 2015, 21, 4756-4764, http://dx.

show abstract

ChemInform Abstract: Regioselective, One‐Pot, Three‐Component Synthesis of 1,3,4‐ and 1,3,5‐Triarylpyrazoles from 1‐ and 2‐Aryl‐1‐alkenyl Sulfones.

Fuse

Sugiyama

Kobayashi

et al. 2015

ChemInform

View full text Add to dashboard Cite

show abstract

Sodium Arenesulfinates‐Involved Sulfinate Synthesis Revisited: Improved Synthesis and Revised Reaction Mechanism

Zhang

2019

Eur J Org Chem

View full text Add to dashboard Cite

Reaction of alcohols with sodium arenesulfinates could afford either sulfones or sulfinates, and O‐attack of sulfinate anions onto the in situ generated carbocation intermediates from alcohols was the previous proposed reaction mechanism in many syntheses of sulfinates. This concept, which is often used consciously or unconsciously, was revised herein by using isotopic labeling experiments and development of an improved sulfinate synthesis. The improved sulfinate synthetic protocol possesses many advantages such as a high sulfinate/sulfone selectivity, a broad substrate scope, metal‐free, and mild reaction conditions. The revised reaction mechanism necessitates revision of many previous proposed reaction mechanisms in literatures.

show abstract

The structural, electro-optical, charge transport and nonlinear optical properties of 2-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylidene]indan-1,3-dione

Irfan

Chaudhry

Muhammad

et al. 2016

Optik

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Regioselective, One‐Pot, Three‐Component Synthesis of 1,3,4‐ and 1,3,5‐Triarylpyrazoles from 1‐ and 2‐Aryl‐1‐alkenyl Sulfones

Cited by 7 publications

References 46 publications

ChemInform Abstract: Regioselective, One‐Pot, Three‐Component Synthesis of 1,3,4‐ and 1,3,5‐Triarylpyrazoles from 1‐ and 2‐Aryl‐1‐alkenyl Sulfones.

ChemInform Abstract: Regioselective, One‐Pot, Three‐Component Synthesis of 1,3,4‐ and 1,3,5‐Triarylpyrazoles from 1‐ and 2‐Aryl‐1‐alkenyl Sulfones.

Sodium Arenesulfinates‐Involved Sulfinate Synthesis Revisited: Improved Synthesis and Revised Reaction Mechanism

The structural, electro-optical, charge transport and nonlinear optical properties of 2-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylidene]indan-1,3-dione

Contact Info

Product

Resources

About