Regionally Selective Atrophy After Traumatic Axonal Injury

Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging

“…In contrast to Warner et al [ 16 ], significant changes for the cerebellum but not for the amygdala were found. However, when comparing to other studies the substantial heterogeneity of TBI studies must be considered: In comparison to the study presented in here, Warner et al [ 16 ] analysed 25 patients with DAI and 22 age-matched controls where patients had a lower GCS of 6.2±4.5 (mean±SD) and were much younger (26.8±11.3 years).…”

Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging

“…In contrast to Warner et al [ 16 ], significant changes for the cerebellum but not for the amygdala were found. However, when comparing to other studies the substantial heterogeneity of TBI studies must be considered: In comparison to the study presented in here, Warner et al [ 16 ] analysed 25 patients with DAI and 22 age-matched controls where patients had a lower GCS of 6.2±4.5 (mean±SD) and were much younger (26.8±11.3 years).…”

Subcortical Volume Loss in the Thalamus, Putamen, and Pallidum, Induced by Traumatic Brain Injury, Is Associated With Motor Performance Deficits

“…13,16,18 -20,22,23,40 Regarding the volumetric cortical regional group differences, however, we could not replicate previously reported cortical GM atrophy in several specific (small) cortical regions. 13,17,18,20,21 Variations of findings across these studies are perhaps driven by the methodological differences in volumetric analysis and the diversity in clinical profiles of the patients. Altogether, the volumetric group differences observed in the present study fit well with those of Kim et al, 19 who reported atrophy in prominent subcortical nuclei in chronic TBI.…”

“…Moreover, with respect to the volumetric global and subcortical regional group differences, our results are largely in line with findings of previous studies. 13,16,[18][19][20]22,23,40 Regarding the volumetric cortical regional group differences, however, we could not replicate previously reported cortical GM atrophy in several specific (small) cortical regions. 13,17,18,20,21 Variations of findings across these studies are perhaps driven by the methodological differences in volumetric analysis and the diversity in clinical profiles of the patients.…”

Relationship of Cerebral Blood Flow to Cognitive Function and Recovery in Early Chronic Traumatic Brain Injury

“…Structural analysis revealed findings consistent with diffuse brain atrophy among the TBI group, which was significantly correlated to injury severity and contemporaneous neurocognitive deficits. This is consistent with several previous studies assessing TBI-related brain volumetric changes [49][50][51] and, additionally, suggests that diffuse brain atrophy is readily apparent as early as 3 months after injury. The lack of detection of focal gray matter volume loss in this study most likely owes to the low statistical power of our small sample size for detection of spatially heterogeneous effects; however, we were able to detect widespread reductions in CBF, suggesting that ASL is more sensitive to gray matter damage than cross-sectional tensor-based morphometry in the early chronic post-TBI period.…”

Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging

“…In contrast to Warner et al [ 16 ], significant changes for the cerebellum but not for the amygdala were found. However, when comparing to other studies the substantial heterogeneity of TBI studies must be considered: In comparison to the study presented in here, Warner et al [ 16 ] analysed 25 patients with DAI and 22 age-matched controls where patients had a lower GCS of 6.2±4.5 (mean±SD) and were much younger (26.8±11.3 years).…”

Subcortical Volume Loss in the Thalamus, Putamen, and Pallidum, Induced by Traumatic Brain Injury, Is Associated With Motor Performance Deficits

“…13,16,18 -20,22,23,40 Regarding the volumetric cortical regional group differences, however, we could not replicate previously reported cortical GM atrophy in several specific (small) cortical regions. 13,17,18,20,21 Variations of findings across these studies are perhaps driven by the methodological differences in volumetric analysis and the diversity in clinical profiles of the patients. Altogether, the volumetric group differences observed in the present study fit well with those of Kim et al, 19 who reported atrophy in prominent subcortical nuclei in chronic TBI.…”

“…Moreover, with respect to the volumetric global and subcortical regional group differences, our results are largely in line with findings of previous studies. 13,16,[18][19][20]22,23,40 Regarding the volumetric cortical regional group differences, however, we could not replicate previously reported cortical GM atrophy in several specific (small) cortical regions. 13,17,18,20,21 Variations of findings across these studies are perhaps driven by the methodological differences in volumetric analysis and the diversity in clinical profiles of the patients.…”

Relationship of Cerebral Blood Flow to Cognitive Function and Recovery in Early Chronic Traumatic Brain Injury

“…Structural analysis revealed findings consistent with diffuse brain atrophy among the TBI group, which was significantly correlated to injury severity and contemporaneous neurocognitive deficits. This is consistent with several previous studies assessing TBI-related brain volumetric changes [49][50][51] and, additionally, suggests that diffuse brain atrophy is readily apparent as early as 3 months after injury. The lack of detection of focal gray matter volume loss in this study most likely owes to the low statistical power of our small sample size for detection of spatially heterogeneous effects; however, we were able to detect widespread reductions in CBF, suggesting that ASL is more sensitive to gray matter damage than cross-sectional tensor-based morphometry in the early chronic post-TBI period.…”

Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging

“…In contrast to Warner et al [ 16 ], significant changes for the cerebellum but not for the amygdala were found. However, when comparing to other studies the substantial heterogeneity of TBI studies must be considered: In comparison to the study presented in here, Warner et al [ 16 ] analysed 25 patients with DAI and 22 age-matched controls where patients had a lower GCS of 6.2±4.5 (mean±SD) and were much younger (26.8±11.3 years).…”

Subcortical Volume Loss in the Thalamus, Putamen, and Pallidum, Induced by Traumatic Brain Injury, Is Associated With Motor Performance Deficits

“…13,16,18 -20,22,23,40 Regarding the volumetric cortical regional group differences, however, we could not replicate previously reported cortical GM atrophy in several specific (small) cortical regions. 13,17,18,20,21 Variations of findings across these studies are perhaps driven by the methodological differences in volumetric analysis and the diversity in clinical profiles of the patients. Altogether, the volumetric group differences observed in the present study fit well with those of Kim et al, 19 who reported atrophy in prominent subcortical nuclei in chronic TBI.…”

“…Moreover, with respect to the volumetric global and subcortical regional group differences, our results are largely in line with findings of previous studies. 13,16,[18][19][20]22,23,40 Regarding the volumetric cortical regional group differences, however, we could not replicate previously reported cortical GM atrophy in several specific (small) cortical regions. 13,17,18,20,21 Variations of findings across these studies are perhaps driven by the methodological differences in volumetric analysis and the diversity in clinical profiles of the patients.…”

Relationship of Cerebral Blood Flow to Cognitive Function and Recovery in Early Chronic Traumatic Brain Injury

“…Structural analysis revealed findings consistent with diffuse brain atrophy among the TBI group, which was significantly correlated to injury severity and contemporaneous neurocognitive deficits. This is consistent with several previous studies assessing TBI-related brain volumetric changes [49][50][51] and, additionally, suggests that diffuse brain atrophy is readily apparent as early as 3 months after injury. The lack of detection of focal gray matter volume loss in this study most likely owes to the low statistical power of our small sample size for detection of spatially heterogeneous effects; however, we were able to detect widespread reductions in CBF, suggesting that ASL is more sensitive to gray matter damage than cross-sectional tensor-based morphometry in the early chronic post-TBI period.…”