J. Neurosci. Res. volume 86, issue 9, P2016-2027 2008 DOI: 10.1002/jnr.21654 View full text
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J. T. García Navia, M. A. Burguillos, A. Ramón‐Cueto, A. Machado, J. Cano, J. L. Venero

Abstract: Axotomy is a powerful stimulus of axon growth and plastic changes. We investigated the potential role of BDNF/trkB signaling in the sprouting of dopaminergic nigral axons in response to axotomy of the medial forebrain bundle. Tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in the axotomized substantia nigra (SN). Time-course changes of trkB mRNA expression demonstrated a robust increase in an area projecting from the rostral tip of the SN to the glial scar, which coinci…

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