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citations
Cited by 194 publications
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References 26 publications
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“…The results show a short initial inflating stage preceding a long phase of linear behaviour, followed by sudden stiffening at about 4 kPa (0.004 N mm −2 ). Based on the results of earlier studies by Woo et al (1972) and Hjortdal (1993Hjortdal ( , 1998 on the corneal microstructure and what has been found in current laboratory testing, it is suggested that the stressstrain relationship is divided into two distinctive phases: a matrix regulated phase with low stiffness followed by a collagen regulated phase with much higher stiffness, as seen in figure 5. In the first phase, the behaviour is dominated by the corneal matrix, particularly within the stroma layer.…”
Section: Resultsmentioning
confidence: 83%
“…The results show a short initial inflating stage preceding a long phase of linear behaviour, followed by sudden stiffening at about 4 kPa (0.004 N mm −2 ). Based on the results of earlier studies by Woo et al (1972) and Hjortdal (1993Hjortdal ( , 1998 on the corneal microstructure and what has been found in current laboratory testing, it is suggested that the stressstrain relationship is divided into two distinctive phases: a matrix regulated phase with low stiffness followed by a collagen regulated phase with much higher stiffness, as seen in figure 5. In the first phase, the behaviour is dominated by the corneal matrix, particularly within the stroma layer.…”
Section: Resultsmentioning
confidence: 83%
“…Measurements of corneal and scleral elasticity are further complicated by the organisation of their fibrillar structure: fibres are oriented in different directions and these directions vary across layers 9 and with progression from the centre to the periphery. [11][12] Hjortdal 14 has addressed some of these points in a very elegant study on 18 human corneae in which he measured the elastic moduli of the different parts of the cornea in both meridional and circumferential directions. He found that in the limbal region, Young's modulus is highest in the circumferential but lowest in the meridional directions and that the highest modulus of all regions and directions was the circumferential limbal value.…”
Section: Discussionmentioning
confidence: 99%
“…From an experimental perspective, the undesirable nonphysiological nature of the tensile test and the corresponding need for preconditioning cycles may be overcome by inflation tests (see, e.g. [16,34,25]). From a modeling perspective, the classical separable QLV does not appear to be sufficient to represent the observed stress-dependent non-linearities.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies on cornea mechanics have typically employed a tensile strip method [64,3,35,45,89,86], or a more physiologically relevant inflation method [88,44,34,77]. These measurements have been used, for example, to study the efficacy of cross-linking agents as means to counteract keratoconous [86,80].…”
Section: Introductionmentioning
confidence: 99%