Regional differences in the association of cytomegalovirus seropositivity and multiple sclerosis: A systematic review and meta-analysis

Thakolwiboon, Smathorn; Zhao-Fleming, Hannah; Pachariyanon, Pavida; Williams, Hayley Gibler; Avila, Mirla

doi:10.1016/j.msard.2020.102393

Cited by 15 publications

(7 citation statements)

References 42 publications

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“…16 Different types of viral infections such as hepatitis C virus (HCV), 17 CMV, 18 dengue virus, 19 and parvovirus B19 20,21 have been postulated to be associated with systemic lupus erythematosus (SLE) that represent a wide variety of autoimmune manifestations. Furthermore, multiple sclerosis (MS) has been found to be associated with Epstein-Barr virus (EBV), 22 measles virus, 23 Varicella-zoster virus, 24 and CMV 25,26 (Table 1). The aforementioned examples support the role of viral infections in the initiation of autoimmune diseases particularly in individuals with genetic susceptibility.…”

Section: Infection and Autoimmunitymentioning

confidence: 99%

Autoimmune complications of COVID‐19

Yazdanpanah

Rezaei

2021

Journal of Medical Virology

132

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Coronavirus disease 2019 (COVID-19) is still propagating a year after the start of the pandemic. Besides the complications patients face during the COVID-19 disease period, there is an accumulating body of evidence concerning the late-onset complications of COVID-19, of which autoimmune manifestations have attracted remarkable attention from the first months of the pandemic. Autoimmune hemolytic anemia, immune thrombocytopenic purpura, autoimmune thyroid diseases, Kawasaki disease, Guillain-Barre syndrome, and the detection of autoantibodies are the cues to the discovery of the potential of COVID-19 in inducing autoimmunity.Clarification of the pathophysiology of COVID-19 injuries to the host, whether it is direct viral injury or autoimmunity, could help to develop appropriate treatment.

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Section: Infection and Autoimmunitymentioning

confidence: 99%

Autoimmune complications of COVID‐19

Yazdanpanah

Rezaei

2021

Journal of Medical Virology

132

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“…It is a common virus and becomes latent. Its association with multiple sclerosis is not conclusive [99,100]. A number of studies suggest a much stronger link with the viruses discussed in the sections above [100,101].…”

Section: Cytomegalovirus (Cmv)mentioning

confidence: 99%

Viral Proteins with PxxP and PY Motifs May Play a Role in Multiple Sclerosis

Sang

Straus

2022

Viruses

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Multiple sclerosis (MS) is a debilitating disease that arises from immune system attacks to the protective myelin sheath that covers nerve fibers and ensures optimal communication between brain and body. Although the cause of MS is unknown, a number of factors, which include viruses, have been identified as increasing the risk of displaying MS symptoms. Specifically, the ubiquitous and highly prevalent Epstein–Barr virus, human herpesvirus 6, cytomegalovirus, varicella–zoster virus, and other viruses have been identified as potential triggering agents. In this review, we examine the specific role of proline-rich proteins encoded by these viruses and their potential role in MS at a molecular level.

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“…The disease starts with a relapsing–remitting clinical form and becomes progressively chronic in later clinical phases [ 114 ]. The etiology of MS is heterogeneous including an interrelationship between genetic factors, principally immune associated genes, and environmental factors such as infectious agents, vitamin D deficiency, sun exposure, obesity, and smoking [ 115 , 116 , 117 ].…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?

De Francesco

2024

Viruses

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Alzheimer’s disease and Parkinson’s disease represent the most common forms of cognitive impairment. Multiple sclerosis is a chronic inflammatory disease of the central nervous system responsible for severe disability. An aberrant immune response is the cause of myelin destruction that covers axons in the brain, spinal cord, and optic nerves. Systemic lupus erythematosus is an autoimmune disease characterized by alteration of B cell activation, while Sjögren’s syndrome is a heterogeneous autoimmune disease characterized by altered immune responses. The etiology of all these diseases is very complex, including an interrelationship between genetic factors, principally immune associated genes, and environmental factors such as infectious agents. However, neurodegenerative and autoimmune diseases share proinflammatory signatures and a perturbation of adaptive immunity that might be influenced by herpesviruses. Therefore, they might play a critical role in the disease pathogenesis. The aim of this review was to summarize the principal findings that link herpesviruses to both neurodegenerative and autoimmune diseases; moreover, briefly underlining the potential therapeutic approach of virus vaccination and antivirals.

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Regional differences in the association of cytomegalovirus seropositivity and multiple sclerosis: A systematic review and meta-analysis

Cited by 15 publications

References 42 publications

Autoimmune complications of COVID‐19

Autoimmune complications of COVID‐19

Viral Proteins with PxxP and PY Motifs May Play a Role in Multiple Sclerosis

Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?

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