Regional difference in intratumoral lymphangiogenesis of oral squamous cell carcinomas evaluated by immunohistochemistry using D2‐40 and podoplanin antibody: an analysis in comparison with angiogenesis

Ohno, Fumi; Nakanishi, Hayao; Abe, Atsushi; Seki, Yasushi; Kinoshita, Atsutaka; Hasegawa, Yasuhisa; Tatematsu, Masae; Kurita, K.

doi:10.1111/j.1600-0714.2007.00529.x

Cited by 28 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1. These results confirm the observation that tumor cells of OSCC, in the early stage of development, express VEGF-C 11,16,17,20,21,25,33,35,36,41,44 , which may elevate the risk of precocious nodal metastasis.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Expression of vascular endothelial growth factor-C does not predict occult lymph-node metastasis in early oral squamous cell carcinoma

Faustino

Oliveira

Nonogaki

et al. 2008

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

“…Evidence is emerging to correlate the presence of VEGF-C expression in tumor cells with an increased likelihood of lymph-node metastases, and consequently to suggest it as a prognostic indicator in oral cancer 11,16,17,20,21,25,33,35,36,41,44 .…”

mentioning

confidence: 99%

Expression of vascular endothelial growth factor-C does not predict occult lymph-node metastasis in early oral squamous cell carcinoma

Faustino

Oliveira

Nonogaki

et al. 2008

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…However, in human tumors this correlation has not always been found. There are contradictory results in different cancers or even in the same type of tumor with regard to VEGF-C expression and lymphangiogenesis or nodal metastasis [6,20,28]. In the current series, carcinomas with high-and low/moderate-risk for nodal metastasis presented similar expressions of VEGF-C.…”

Section: Discussionsupporting

confidence: 53%

Lymphatic vessel density and expressions of lymphangiogenic growth factors in salivary carcinomas

Mf¹,

Af²,

Ll³

et al. 2011

neo

View full text Add to dashboard Cite

Nodal metastasis is an important prognostic indicator in head and neck cancers, including salivary carcinomas. In these, the risk for lymph node metastasis is variable and strongly associated with the tumor histologic type. The aim of the current study was to evaluate the lymphatic vessel density (LVD) and expressions of lymphangiogenic growth factors by tumor cells in different histologic types of salivary carcinomas subdivided according to the risk for nodal metastasis. In 15 high-risk (undifferentiated, high-grade mucoepidermoid and salivary duct carcinomas) and 60 low/moderate-risk tumors (adenoid cystic, low/intermediate-grade mucoepidermoid, acinic cell, myoepithelial, epithelial-myoepithelial and polymorphic lowgrade carcinomas) the expressions of vascular endothelial growth factor-C (VEGF-C), hepatocyte growth factor (HGF) and D2-40 (for assessing LVD) were examined. No significant differences were encountered between high-and low/moderate/-risk carcinomas regarding LVD and VEGF-C or HGF expressions. Furthermore, the expression of these proteins did not correlate with LVD. Lymphatic vascular invasion was found mainly in high-risk carcinomas. Intratumoral LVD was significantly lower than peritumoral, regardless of the risk for metastasis and primary site of the lesion. The histologic types of salivary carcinomas which are associated with high-risk for nodal metastasis do not present increased LVD or VEGF-C and HGF expressions. The greater tendency for metastasis in these carcinomas seems to be related to their capacity to invade lymph vessels. Further studies on tumor cell interactions with lymphatic endothelial cells are needed to improve our understanding of the metastatic potential of salivary carcinomas. Key words: lymph vessels, salivary carcinoma, VEGF-C, HGF.Nodal metastasis is an important prognostic predictor in head and neck cancers, including salivary carcinomas. The risk for lymph node metastasis in these carcinomas is highly variable (9% -85%) [1] and strongly associated with the tumor histologic type [1][2][3][4][5]. It is a general consensus that high-grade mucoepidermoid carcinomas, salivary duct carcinomas, undifferentiated carcinomas and squamous cell carcinomas are high-risk tumors for nodal metastasis [1,[3][4][5]. In these the risk for neck metastasis has been described to be >50% [1] and, thus, elective neck dissection is considered in their management [1][2][3].Lymph vessels provide the main avenue for nodal metastasis and in head and neck squamous cell carcinoma (HNSCC) it has been shown that tumors of different anatomic regions do not vary significantly in their lymphangiogenic properties [6,7]. However, a high lymph vessel density (LVD) seems to be an indicator of the risk of lymph node metastasis in HNSCC [6][7][8][9]. Regarding salivary gland tumors, the lymphatic vessels have rarely been studied [10][11][12] and in a particular type of salivary carcinoma, i.e. in those arising in pleomorphic adenomas (CXPA) the lymphatic network was found to be composed mainly of pre-existing ...

show abstract

“…The other possibility could be that VEGF-C expression was down regulated in the intra tumoural tissue, especially in the deeper area near the invasive front. Alternatively, it can be speculated that a natural inhibitor of lymphangiogenesis may be present in the tumour stroma [14].…”

Section: Discussionmentioning

confidence: 99%

Characterization, Localization and Patterning of Lymphatics and Blood Vessels in Oral Squamous Cell Carcinoma: A Comparative Study Using D2-40 and CD-34 IHC Marker

Pardhe

Bajpai

et al. 2014

JCDR

View full text Add to dashboard Cite

Regional difference in intratumoral lymphangiogenesis of oral squamous cell carcinomas evaluated by immunohistochemistry using D2‐40 and podoplanin antibody: an analysis in comparison with angiogenesis

Cited by 28 publications

References 28 publications

Expression of vascular endothelial growth factor-C does not predict occult lymph-node metastasis in early oral squamous cell carcinoma

Expression of vascular endothelial growth factor-C does not predict occult lymph-node metastasis in early oral squamous cell carcinoma

Lymphatic vessel density and expressions of lymphangiogenic growth factors in salivary carcinomas

Characterization, Localization and Patterning of Lymphatics and Blood Vessels in Oral Squamous Cell Carcinoma: A Comparative Study Using D2-40 and CD-34 IHC Marker

Contact Info

Product

Resources

About