Regional Cerebral Blood Flow in Patients With Leuko-Araiosis and Atherosclerotic Carotid Artery Disease

Lack of Association of White Matter Lesions with Ipsilateral Carotid Artery Stenosis

“…Only 3 studies assessed the relationship between increasing carotid stenosis and ipsilateral WML (n = 1,395) [26,27,28], but 2 used CT, which is less sensitive to WML than MRI [27,28], and the third was small [26]. Our results are in agreement with those of Herholz et al [29], who assessed asymmetric WML versus asymmetric carotid stenosis, but in only 20 patients. Our findings are also similar to those of Altaf et al [26], although these authors did not consider carotid artery/hemispheres in relation to symptoms.…”

“…Several studies suggest that carotid stenosis is infrequent in lacunar stroke such that it may be coincidental [19], despite which, emboli may still be regarded as an important cause of lacunar stroke and WML. Amongst 12 previous studies (n = 7,843) assessing carotid stenosis versus WML score, 2 (n = 2,118) found an association between increasing stenosis and increasing total brain (not ipsilateral ) WML and 10 (n = 5,725) did not (table 4) [18,20,21,22,23,24,25,26,27,28,29]. The populations and research methods differed in these studies; only some adjusted for some risk factors or age, so it is possible that any association between stenosis and WML is actually due to co-association with a third factor, e.g.…”

Lack of Association of White Matter Lesions with Ipsilateral Carotid Artery Stenosis

“…Only 3 studies assessed the relationship between increasing carotid stenosis and ipsilateral WML (n = 1,395) [26,27,28], but 2 used CT, which is less sensitive to WML than MRI [27,28], and the third was small [26]. Our results are in agreement with those of Herholz et al [29], who assessed asymmetric WML versus asymmetric carotid stenosis, but in only 20 patients. Our findings are also similar to those of Altaf et al [26], although these authors did not consider carotid artery/hemispheres in relation to symptoms.…”

“…Several studies suggest that carotid stenosis is infrequent in lacunar stroke such that it may be coincidental [19], despite which, emboli may still be regarded as an important cause of lacunar stroke and WML. Amongst 12 previous studies (n = 7,843) assessing carotid stenosis versus WML score, 2 (n = 2,118) found an association between increasing stenosis and increasing total brain (not ipsilateral ) WML and 10 (n = 5,725) did not (table 4) [18,20,21,22,23,24,25,26,27,28,29]. The populations and research methods differed in these studies; only some adjusted for some risk factors or age, so it is possible that any association between stenosis and WML is actually due to co-association with a third factor, e.g.…”

Magnetic Resonance Imaging in Patients With Low-Tension Glaucoma

“…24 Consequently, this finding of intracranial ische¬ mie changes provides a hypothesis for a vascular cause, at least in some patients, of low-tension glaucoma.…”

2015 ParaPan American Games: Autonomic Function, But Not Physical Activity, Is Associated with Vascular-Cognitive Impairment in Spinal Cord Injury

“…For the first time, our findings clearly indicate that while MCA flow is preserved, there is selective reduction in posterior cerebral perfusion (as indicated by reduced PCA flow) after SCI. It is known that cerebral hypoperfusion contributes to white matter damage, 23 and hypoperfusion of the brainstem (where autonomic control centers and regions for consciousness are located) likely underlies the high incidence of presyncope/syncope in this population. 1 These data, and our work demonstrating posterior reversible encephalopathy syndrome after SCI, illustrate susceptibility of posterior cerebrovasculature to hyperperfusion and hypoperfusion.…”

Lack of Association of White Matter Lesions with Ipsilateral Carotid Artery Stenosis

“…Only 3 studies assessed the relationship between increasing carotid stenosis and ipsilateral WML (n = 1,395) [26,27,28], but 2 used CT, which is less sensitive to WML than MRI [27,28], and the third was small [26]. Our results are in agreement with those of Herholz et al [29], who assessed asymmetric WML versus asymmetric carotid stenosis, but in only 20 patients. Our findings are also similar to those of Altaf et al [26], although these authors did not consider carotid artery/hemispheres in relation to symptoms.…”

“…Several studies suggest that carotid stenosis is infrequent in lacunar stroke such that it may be coincidental [19], despite which, emboli may still be regarded as an important cause of lacunar stroke and WML. Amongst 12 previous studies (n = 7,843) assessing carotid stenosis versus WML score, 2 (n = 2,118) found an association between increasing stenosis and increasing total brain (not ipsilateral ) WML and 10 (n = 5,725) did not (table 4) [18,20,21,22,23,24,25,26,27,28,29]. The populations and research methods differed in these studies; only some adjusted for some risk factors or age, so it is possible that any association between stenosis and WML is actually due to co-association with a third factor, e.g.…”

Magnetic Resonance Imaging in Patients With Low-Tension Glaucoma

“…24 Consequently, this finding of intracranial ische¬ mie changes provides a hypothesis for a vascular cause, at least in some patients, of low-tension glaucoma.…”

2015 ParaPan American Games: Autonomic Function, But Not Physical Activity, Is Associated with Vascular-Cognitive Impairment in Spinal Cord Injury

“…For the first time, our findings clearly indicate that while MCA flow is preserved, there is selective reduction in posterior cerebral perfusion (as indicated by reduced PCA flow) after SCI. It is known that cerebral hypoperfusion contributes to white matter damage, 23 and hypoperfusion of the brainstem (where autonomic control centers and regions for consciousness are located) likely underlies the high incidence of presyncope/syncope in this population. 1 These data, and our work demonstrating posterior reversible encephalopathy syndrome after SCI, illustrate susceptibility of posterior cerebrovasculature to hyperperfusion and hypoperfusion.…”

Lack of Association of White Matter Lesions with Ipsilateral Carotid Artery Stenosis

“…Only 3 studies assessed the relationship between increasing carotid stenosis and ipsilateral WML (n = 1,395) [26,27,28], but 2 used CT, which is less sensitive to WML than MRI [27,28], and the third was small [26]. Our results are in agreement with those of Herholz et al [29], who assessed asymmetric WML versus asymmetric carotid stenosis, but in only 20 patients. Our findings are also similar to those of Altaf et al [26], although these authors did not consider carotid artery/hemispheres in relation to symptoms.…”

“…Several studies suggest that carotid stenosis is infrequent in lacunar stroke such that it may be coincidental [19], despite which, emboli may still be regarded as an important cause of lacunar stroke and WML. Amongst 12 previous studies (n = 7,843) assessing carotid stenosis versus WML score, 2 (n = 2,118) found an association between increasing stenosis and increasing total brain (not ipsilateral ) WML and 10 (n = 5,725) did not (table 4) [18,20,21,22,23,24,25,26,27,28,29]. The populations and research methods differed in these studies; only some adjusted for some risk factors or age, so it is possible that any association between stenosis and WML is actually due to co-association with a third factor, e.g.…”

Magnetic Resonance Imaging in Patients With Low-Tension Glaucoma

“…24 Consequently, this finding of intracranial ische¬ mie changes provides a hypothesis for a vascular cause, at least in some patients, of low-tension glaucoma.…”

2015 ParaPan American Games: Autonomic Function, But Not Physical Activity, Is Associated with Vascular-Cognitive Impairment in Spinal Cord Injury

“…For the first time, our findings clearly indicate that while MCA flow is preserved, there is selective reduction in posterior cerebral perfusion (as indicated by reduced PCA flow) after SCI. It is known that cerebral hypoperfusion contributes to white matter damage, 23 and hypoperfusion of the brainstem (where autonomic control centers and regions for consciousness are located) likely underlies the high incidence of presyncope/syncope in this population. 1 These data, and our work demonstrating posterior reversible encephalopathy syndrome after SCI, illustrate susceptibility of posterior cerebrovasculature to hyperperfusion and hypoperfusion.…”