Regional alterations of brain biogenic amines in young rats following chronic lead exposure

Infant Exposure to Lead (Pb) and Epigenetic Modifications in the Aging Primate Brain: Implications for Alzheimer's Disease

“…Besides its involvement in the control of locomotor activity, it also regulates the release of other neurotransmitters. Studies have shown that Pb affects monoamine levels in the brain including serotonin, which is widely distributed throughout the brain and, in particular, in regions associated with anxiety [46,47]. Consistent with our array results, other genes like the DNM2, DOR1, and RAB-5C were also downregulated.…”

Infant Exposure to Lead (Pb) and Epigenetic Modifications in the Aging Primate Brain: Implications for Alzheimer's Disease

“…Besides its involvement in the control of locomotor activity, it also regulates the release of other neurotransmitters. Studies have shown that Pb affects monoamine levels in the brain including serotonin, which is widely distributed throughout the brain and, in particular, in regions associated with anxiety [46,47]. Consistent with our array results, other genes like the DNM2, DOR1, and RAB-5C were also downregulated.…”

The inhibition of cerebral high affinity receptor sites by lead and mercury compounds

“…The effects of organic and inorganic lead compounds on the central nervous system resemble the effects of anticholinergic drugs in that they include ataxia, restlessness, irritability and confusion (Abood 1968;Kehoe 1976;Aldridge 1978). However, several of these signs may be associated with dopaminergic impairment (Silbergeld and Goldberg 1975;Reiter and Ash 1976;Govoni et al 1979;Dubas et al 1978). Exposure to lead is extremely prevalent (Grandjean 1978) and it may be that the inhibition of transmitter binding reported here accounts in part for some of the disturbances associated with heavy metal poisoning.…”

Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co‐administration

“…Developing rats at PND 35 were found to be more vulnerable to Pb‐toxicity as compared to early and late PND. Pb‐exposure is known to alter the cholinergic and aminergic systems during development of the central nervous system (Reddy et al, 2007; Devi et al, 2005; Antonio and Leret, 2000; Bressler and Goldstein, 1991) which again is dose dependent (Dubas et al, 1978). The age dependent alterations observed in the early postnatal age might be due to under developed blood‐brain‐barrier (Willes et al, 1977) and increased gastrointestinal absorption of Pb (Dorea and Donangelo, 2006; Ziegler et al, 1978).…”

Infant Exposure to Lead (Pb) and Epigenetic Modifications in the Aging Primate Brain: Implications for Alzheimer's Disease

“…Besides its involvement in the control of locomotor activity, it also regulates the release of other neurotransmitters. Studies have shown that Pb affects monoamine levels in the brain including serotonin, which is widely distributed throughout the brain and, in particular, in regions associated with anxiety [46,47]. Consistent with our array results, other genes like the DNM2, DOR1, and RAB-5C were also downregulated.…”

The inhibition of cerebral high affinity receptor sites by lead and mercury compounds

“…The effects of organic and inorganic lead compounds on the central nervous system resemble the effects of anticholinergic drugs in that they include ataxia, restlessness, irritability and confusion (Abood 1968;Kehoe 1976;Aldridge 1978). However, several of these signs may be associated with dopaminergic impairment (Silbergeld and Goldberg 1975;Reiter and Ash 1976;Govoni et al 1979;Dubas et al 1978). Exposure to lead is extremely prevalent (Grandjean 1978) and it may be that the inhibition of transmitter binding reported here accounts in part for some of the disturbances associated with heavy metal poisoning.…”

Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co‐administration

“…Developing rats at PND 35 were found to be more vulnerable to Pb‐toxicity as compared to early and late PND. Pb‐exposure is known to alter the cholinergic and aminergic systems during development of the central nervous system (Reddy et al, 2007; Devi et al, 2005; Antonio and Leret, 2000; Bressler and Goldstein, 1991) which again is dose dependent (Dubas et al, 1978). The age dependent alterations observed in the early postnatal age might be due to under developed blood‐brain‐barrier (Willes et al, 1977) and increased gastrointestinal absorption of Pb (Dorea and Donangelo, 2006; Ziegler et al, 1978).…”

Infant Exposure to Lead (Pb) and Epigenetic Modifications in the Aging Primate Brain: Implications for Alzheimer's Disease

“…Besides its involvement in the control of locomotor activity, it also regulates the release of other neurotransmitters. Studies have shown that Pb affects monoamine levels in the brain including serotonin, which is widely distributed throughout the brain and, in particular, in regions associated with anxiety [46,47]. Consistent with our array results, other genes like the DNM2, DOR1, and RAB-5C were also downregulated.…”

The inhibition of cerebral high affinity receptor sites by lead and mercury compounds

“…The effects of organic and inorganic lead compounds on the central nervous system resemble the effects of anticholinergic drugs in that they include ataxia, restlessness, irritability and confusion (Abood 1968;Kehoe 1976;Aldridge 1978). However, several of these signs may be associated with dopaminergic impairment (Silbergeld and Goldberg 1975;Reiter and Ash 1976;Govoni et al 1979;Dubas et al 1978). Exposure to lead is extremely prevalent (Grandjean 1978) and it may be that the inhibition of transmitter binding reported here accounts in part for some of the disturbances associated with heavy metal poisoning.…”

Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co‐administration

“…Developing rats at PND 35 were found to be more vulnerable to Pb‐toxicity as compared to early and late PND. Pb‐exposure is known to alter the cholinergic and aminergic systems during development of the central nervous system (Reddy et al, 2007; Devi et al, 2005; Antonio and Leret, 2000; Bressler and Goldstein, 1991) which again is dose dependent (Dubas et al, 1978). The age dependent alterations observed in the early postnatal age might be due to under developed blood‐brain‐barrier (Willes et al, 1977) and increased gastrointestinal absorption of Pb (Dorea and Donangelo, 2006; Ziegler et al, 1978).…”