2017
DOI: 10.1055/s-0037-1608761 View full text |Buy / Rent full text
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Abstract: For more than 20 years, tremendous efforts have been made to develop cell-based therapies for treatment of heart failure. However, the results of clinical trials using somatic, nonpluripotent stem or progenitor cells have been largely disappointing in both cardiology and cardiac surgery scenarios. Surgical groups were among the pioneers of experimental and clinical myocyte transplantation ("cellular cardiomyoplasty"), but little translational progress was made prior to the development of cellular reprogramming… Show more

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“…These medical challenges have raised the need for innovative and more effective cell-based approaches that are currently the subject of numerous research studies 12 , 13 . To this aim, the tissue engineering and regenerative medicine approaches revealed great potential as alternative options, creating constructs for repairing or replacing macroscopic part of cardiovascular tissue 14 17 .…”
Section: Introductionmentioning
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“…These medical challenges have raised the need for innovative and more effective cell-based approaches that are currently the subject of numerous research studies 12 , 13 . To this aim, the tissue engineering and regenerative medicine approaches revealed great potential as alternative options, creating constructs for repairing or replacing macroscopic part of cardiovascular tissue 14 17 .…”
Section: Introductionmentioning
“…Cardiovascular progenitor cells (CPCs) have been evaluated for numerous applications to treat a variety of cardiovascular diseases from congenital heart defects to myocardial infarctions [1,2]. This population of cells is capable of differentiating into the three cardiac lineages: cardiomyocytes, endothelial, and vascular smooth muscle cells.…”
Section: Introductionmentioning
“…Using a 30 % TBSA burned rat model, Liu L. et al transplanted 5×10 6 GFP-labeled human umbilical cord mesenchymal stem cells (HUCMSCs) at day 3 after burn via a tail vein injection [22] and concluded that HUCMSCs remarkably decreased the quantity of in ltrated in ammatory cells and levels of IL-1, IL-6, TNF-α and increased levels of IL-10 and TSG-6 in wound. In another study, a reduction in the plasma levels of proin ammatory cytokines IL-6, IL-1β and TNF-α was proved to result in a low mortality rate [21].…”
Section: Discussionmentioning
“…In recent decades, although the immunomodulation and anti-in ammation properties of mesenchymal stem cells (MSCs) has ignited a hope in the treatment of SIRS [19][20][21][22][23][24][25][26][27][28], their bene cial effect in reducing the high mortality risk in extensive burns are seldom reported in the literature. Using an animal burn model, the present study investigated the clinical e cacy of human choriodecidual mesenchymal stem cell (hcMSC) in treating extensive burns.…”
Section: Introductionmentioning