Regenerative Medicine and Cell Therapy

Sadri‐Ardekani, Hooman; Atala, Anthony

doi:10.1002/9781118540640.ch4

Cited by 1 publication

(1 citation statement)

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“…In relation to scaffolds, biogels have some advantages, as they require the use of less invasive procedures for their deposition at the target site and facilitate the repair of irregular tissue surfaces due to their viscoelasticity, provided by collagen and other biomolecules that compose them ( 252 ). Thus, in addition to the new possibilities of cell culture to improve in vitro spermatogenesis rates, bioengineering proposes innovative methods of treatment for diseases that affect the reproductive system and the resumption of fertility, such as the application of decellularized matrix scaffolds or biogels ( 217 , 253 ).…”

Section: Discussionmentioning

confidence: 99%

Biomaterials for Testicular Bioengineering: How far have we come and where do we have to go?

et al. 2023

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Traditional therapeutic interventions aim to restore male fertile potential or preserve sperm viability in severe cases, such as semen cryopreservation, testicular tissue, germ cell transplantation and testicular graft. However, these techniques demonstrate several methodological, clinical, and biological limitations, that impact in their results. In this scenario, reproductive medicine has sought biotechnological alternatives applied for infertility treatment, or to improve gamete preservation and thus increase reproductive rates in vitro and in vivo. One of the main approaches employed is the biomimetic testicular tissue reconstruction, which uses tissue-engineering principles and methodologies. This strategy pursues to mimic the testicular microenvironment, simulating physiological conditions. Such approach allows male gametes maintenance in culture or produce viable grafts that can be transplanted and restore reproductive functions. In this context, the application of several biomaterials have been proposed to be used in artificial biological systems. From synthetic polymers to decellularized matrixes, each biomaterial has advantages and disadvantages regarding its application in cell culture and tissue reconstruction. Therefore, the present review aims to list the progress that has been made and the continued challenges facing testicular regenerative medicine and the preservation of male reproductive capacity, based on the development of tissue bioengineering approaches for testicular tissue microenvironment reconstruction.

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Section: Discussionmentioning

confidence: 99%