Regenerative Medicine

Marongiu, Fabio; Serra, Maria Paola; Fanti, Maura; Cadoni, Erika; Serra, Mauro; Laconi, Ezio

doi:10.1177/0963689717721224

Cited by 7 publications

(2 citation statements)

References 71 publications

(92 reference statements)

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“…In order to evaluate whether TRF had any effect on the onset of the neoplastic-prone tissue microenvironment typical of the aged liver [10], animals were exposed to this dietary regimen for 18 months. They were then switched to ALF and they were transplanted with hepatocytes isolated from chemically-induced hepatic nodules (See Methods for details).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, pre-neoplastic hepatocytes were able to progress to form large tumors in aged hosts, while no lesions were detected in animals transplanted at young age even after several months of follow-up [9]. Based on this evidence, we have proposed that a relevant contribution of aging towards increasing the risk of cancer is related to the emergence of an age-associated, clonogenic and neoplastic-prone tissue landscape [10], the declining cellular fitness of the aged tissue being a selective driver for clonal growth, as it has been suggested for the hematopoietic system [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Serra

Marongiu

Pisu

et al. 2019

Aging

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Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF on the emergence of the age-associated, neoplastic-prone tissue landscape. Animals were exposed to either ad libitum feeding (ALF) or TRF for 18 months and then transplanted with hepatocytes isolated from pre-neoplastic nodules. Both groups were continued ALF and the growth of transplanted cells was evaluated 3 months later. A significant decrease in frequency of larger size clusters of pre-neoplastic hepatocytes was seen in TRF-exposed group compared to controls. Furthermore, TRF modified several parameters related to both liver and systemic aging towards the persistence of a younger phenotype, including a decrease in liver cell senescence, diminished fat accumulation and up-regulation of SIRT1 in the liver, down-regulation of plasma IGF-1, decreased levels of plasma lipoproteins and up-regulation of hippocampal brain-derived growth factor (BDNF).These results indicate that TRF was able to delay the onset of the neoplastic-prone tissue landscape typical of aging. To our knowledge, this is the first investigation to describe a direct beneficial effect of TRF on early phases of carcinogenesis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Serra

Marongiu

Pisu

et al. 2019

Aging

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The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

Marongiu

DeGregori

2022

Molecular Oncology

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Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with expanded clones that are frequently driven by cancer‐associated mutations in an aging‐dependent fashion. Additional studies show how aged tissue microenvironments promote the initiation and progression of malignancies, while young healthy tissues actively suppress the outgrowth of malignant clones. Here, we discuss conserved mechanisms that eliminate poorly functioning or potentially malignant cells from our tissues to maintain organismal health and fitness. Natural selection acts to preserve tissue function and prevent disease to maximize reproductive success but these mechanisms wane as reproduction becomes less likely. The ensuing age‐dependent tissue decline can impact the shape and direction of clonal somatic evolution, with lifestyle and exposures influencing its pace and intensity. We also consider how aging‐ and exposure‐dependent clonal expansions of “oncogenic” mutations might both increase cancer risk late in life and contribute to tissue decline and non‐malignant disease. Still, we can marvel at the ability of our bodies to avoid cancers and other diseases despite the accumulation of billions of cells with cancer‐associated mutations.

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Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes?

Bertinat

Westermeier

Gatica

et al. 2018

Journal Cellular Physiology

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Diabetes is a complex metabolic disorder triggered by the deficient secretion of insulin by pancreatic β cells, the resistance of peripheral tissues to the action of the hormone, or both, and is characterized by chronic hyperglycemia leading to organ damage and failure. Tight glycemic control represents the best therapy to delay or stop progression of diabetes, with many antidiabetic drugs being commercially available nowadays. However, no ideal normoglycemic agent has been developed as yet, and those already available still induce hypoglycemia and/or weight gain as major side effects, worsening glycemic control. In this respect, the inorganic salt sodium tungstate (Na WO ) has been proven to offer a good antidiabetic alternative in different animal models of diabetes, reducing body weight and normalizing glycemia without causing hypoglycemic episodes. The mechanisms of action mediating the potent antidiabetic actions but also the spectrum of undesirable effects of Na WO are still poorly understood. In fact, along with its beneficial effects, Na WO has been consistently reported to be toxic and even carcinogenic. Given that Na WO is accumulated in the kidneys for elimination, here, we discuss a possible association between long-term Na WO treatment and a higher risk of renal carcinogenesis in diabetic individuals.

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Regenerative Medicine

Cited by 7 publications

References 71 publications

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes?

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