2015
DOI: 10.5312/wjo.v6.i1.127
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Abstract: Recent advancements in the field of musculoskeletal tissue engineering have raised an increasing interest in the regeneration of the anterior cruciate ligament (ACL). It is the aim of this article to review the current research efforts and highlight promising tissue engineering strategies. The four main components of tissue engineering also apply in several ACL regeneration research efforts. Scaffolds from biological materials, biodegradable polymers and composite materials are used. The main cell sources are … Show more

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Cited by 75 publications
(58 citation statements)
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“…In recent years, tissue engineering (TE) has delivered promising results that might overcome these challenges [9]. Biological materials, biodegradable polymers and composite materials have been developed in ACL reconstruction [9,10].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…In recent years, tissue engineering (TE) has delivered promising results that might overcome these challenges [9]. Biological materials, biodegradable polymers and composite materials have been developed in ACL reconstruction [9,10].…”
Section: Introductionmentioning
confidence: 99%
“…Biological materials, biodegradable polymers and composite materials have been developed in ACL reconstruction [9,10]. Amongst these, silkbased biomaterials have been intensively studied, due to their good biocompatibility, mechanical strength and controllable biodegradability [11].…”
Section: Introductionmentioning
confidence: 99%
“…However current ACL reconstruction techniques generally fail to regenerate the graded structure of the enthesis, predisposing the tissue at the bone insertion site to high stress concentrations which is believed to contribute to high failure rates [5][6][7]. This has motived the development of tissue engineering (TE) strategies for ligament regeneration [8,9]. A number of studies have attempted to engineer stable fibrocartilaginous tissue or a mineral gradient to interface between the calcified region and the main body of the engineered ligament [10][11][12][13][14], although the ideal solution has yet to be identified.…”
Section: Introductionmentioning
confidence: 99%
“…One alternative method could be the treatment of these lesions with tissue engineering (Nau, & Teuschl, 2015). We have investigated a novel tissue engineering approach based in the use of ACL isolated fibroblasts combined with type I/III collagen membranes as a carrier in the reconstruction of broken ACL.…”
Section: Introductionmentioning
confidence: 99%