J. Neurosci. Res. volume 86, issue 14, P3140-3150 2008 DOI: 10.1002/jnr.21767 View full text
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Xichuan Teng, Isao Nagata, Hong-Peng Li, Junko Kimura-Kuroda, Kazunori Sango, Koki Kawamura, Geoffrey Raisman, Hitoshi Kawano

Abstract: The fibrotic scar formed after central nervous system injury has been considered an obstacle to axonal regeneration. The present study was designed to examine whether cell transplantation into a damaged central nervous system can reduce fibrotic scar formation and promote axonal regeneration. Nigrostriatal dopaminergic axons were unilaterally transected in rats and cultures of olfactory-ensheathing cells (OECs), and olfactory nerve fibroblasts were transplanted into the lesion site. In the absence of transplan…

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