Regenerating lizard tails: A new model for investigating lymphangiogenesis

Daniels, Christopher B.; Lewis, Benjamin C.; Tsopelas, Chris; Munns, Suzanne L.; Orgeig, Sandra; Baldwin, Megan E.; Stacker, Steven A.; Achen, Marc G.; Chatterton, Barry E.; Cooter, Rodney D.

doi:10.1096/fj.02-0579fje

Cited by 29 publications

(25 citation statements)

References 18 publications

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“…Such plasticity has been rigorously studied in the primitive epithelial lens (10,11), probably because the eye of newts is a site of immunologic privilege - where immune responses are constrained and tissues protected from inflammation and scarification (9,10). The lizard represents a phylogenic transition toward more complex organisms, as its tail (12,13), but not limbs (14), first scar and then regenerate blastema to replace the missing appendage. Evidence for tissue regeneration in primates is scarce, except in the liver, occasional peripheral neurons, and the finger tips in limited circumstances (15).…”

Section: Epithelial Cell Plasticitymentioning

confidence: 99%

Biomarkers for epithelial-mesenchymal transitions

Zeisberg¹,

Neilson²

2009

J. Clin. Invest.

1,993

1,895

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Somatic cells that change from one mature phenotype to another exhibit the property of plasticity. It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). Published reports from the literature typically rely on ad hoc criteria for determining EMT events; consequently, there is some uncertainty as to whether the same process occurs under different experimental conditions. As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon -namely, the transition of epithelial and endothelial cells to a motile phenotype.

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Section: Epithelial Cell Plasticitymentioning

confidence: 99%

Biomarkers for epithelial-mesenchymal transitions

Zeisberg¹,

Neilson²

2009

J. Clin. Invest.

1,993

1,895

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“…Although wound healing and scarring may be roadblocks for regeneration in most organisms, the lizard provides us with an example that these processes can be coordinated, or at least not interfere. Some lizards can lose substantial portions of their tail by autotomy, and this results in initiation of wound healing with scarring, wound epithelium formation, blastema formation and subsequent regeneration of the tail (Daniels et al 2003;Alibardi & Toni, 2005). After autotomy the spleen is enlarged about 14 times in weight during early stages, and splenectomy can delay wound healing without any obvious effect on the later stages of regeneration (Shah et al 1978).…”

Section: Differences In Immunomodulation During Woundmentioning

confidence: 99%

Regeneration, tissue injury and the immune response

2006

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The involvement of the immune system in the response to tissue injury has raised the possibility that it might influence tissue, organ or appendage regeneration following injury. One hypothesis that has been discussed is that inflammatory aspects may preclude the occurrence of regeneration, but there is also evidence for more positive roles of immune components. The vertebrate eye is an immunoprivileged site where inflammatory aspects are inhibited by several immunomodulatory mechanisms. In various newt species the ocular tissues such as the lens are regenerative and it has recently been shown that the response to local injury of the lens involves activation of antigen-presenting cells which traffic to the spleen and return to displace and engulf the lens, thereby inducing regeneration from the dorsal iris. The activation of thrombin from prothrombin in the dorsal iris is one aspect of the injury response that is important in the initiation of regeneration. The possible relationships between the immune response and the regenerative response are considered with respect to phylogenetic variation of regeneration in general, and lens regeneration in particular.

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“…The first type monitors lymphangiogenesis during wound healing in the mouse tail, 8 -10 the rabbit ear, 9 the rat tail, 10 the lizard tail, 11 or the rat limb. 12 The second type of animal model involves transgenic or viral overexpression of ligands or antagonist molecules usually in the skin.…”

mentioning

confidence: 99%

Spontaneous Corneal Hem- and Lymphangiogenesis in Mice with Destrin-Mutation Depend on VEGFR3 Signaling

Cursiefen

Ikeda

Nishina

et al. 2005

The American Journal of Pathology

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Lymphangiogenesis, the formation of new lymphatic vessels, is important for tumor metastasis and induction of immunity to peripheral antigens including organ transplants. We herein describe a novel mouse model of spontaneous, secondary lymphangiogenesis in the normally avascular cornea. corn1 mice, which suffer from a deletion in the gene encoding the cytoskeletal protein destrin, develop hemangiogenesis as well as spontaneous outgrowth of LYVE-1 ؉؉؉ / CD31 ؉ lymphatic vessels into the cornea starting at age 4 weeks. Corneal lymphangiogenesis is delayed in onset, is less intense, and regresses earlier compared with hemangiogenesis. Moreover, the lymphangiogenesis is preceded only by a mild recruitment of CD45 ؉ inflammatory cells into the cornea. In contrast to mice with inflammation-induced hem-and lymphangiogenesis, corn1 mice do not develop breakdown of the blood-aqueous barrier. Finally, in this novel mouse model, a blocking anti-VEGFR3 antibody significantly inhibited not only lymph-but also hemangiogenesis. In summary, destrin deletion has differential effects on spontaneous hem-and lymphangiogenesis in the normally avascular cornea and Lymphangiogenesis, the development of new lymph vessels, has recently gained wide interest for its important role in tumor metastasis and induction of alloimmunity after organ transplantation (for review, see Refs.

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Regenerating lizard tails: A new model for investigating lymphangiogenesis

Cited by 29 publications

References 18 publications

Biomarkers for epithelial-mesenchymal transitions

Biomarkers for epithelial-mesenchymal transitions

Regeneration, tissue injury and the immune response

Spontaneous Corneal Hem- and Lymphangiogenesis in Mice with Destrin-Mutation Depend on VEGFR3 Signaling

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