Reflux, Allergic Rhinitis, and Sleep Disorders with Asthma Control and Quality of Life

Abstract

Anahtar KelimelerAstım Kontrol Testi; Astım Yaşam Kalitesi; Gastroözefageal Reflü; Alerjik Rinit; Uyku Bozuklukları Abstract Aim: In this study we aimed to investigate the effect of comorbid diseases such as gastroesophageal reflux, allergic rhinitis, sleep disorders with asthma control test and asthma quality of life in Turkish asthma patients. Material and Method: Total of 50 patients who were followed with a diagnosis of asthma were enrolled in this study. During application, spirometric parameters, Reflux Symptom Index (RSI), Allergic Rhinoconjunctivitis Symptom Index (ARSI), Pittsburgh Sleep Quality Index (PSQI), Asthma Control Test (ACT), and Asthma Quality of Life Questionnaires (AQLQ) were filled under the supervision of a physician, also smoking habits, body mass index of cases were recorded. The relation of spirometric parameters, RSI, ARSI and PSQI with AQLQ and ACT tests were investigated by using SPSS 15.0 statistical software. Results: Negative correlation was found between the ACT and RSI (r = -0.314, p = 0.026), 620; p<0.001). Positive correlation was found between ACT and AQLQ (r=0.667, p <0.001), there was no relationship between ACT and ARSI (p=0,25). Negative correlation was found between AQLQ and RSI (r= -0,551; p<0.001), AQLQ and ARSI (r= -0,390; p<0.005). There was no relationship between AQLQ and PSQI (p=0.082), also there was no relationship between FEV1 value and ACT, AQLQ, RSI, ARSI, PSQI. Discussion: In conclusion, gastroesophageal reflux and allergic rhinoconjunctivitis negatively effect the quality of life and asthma control in asthmatic patients, also poor sleep quality is associated with poor asthma control.

Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review

“…Six publications found strong and consistent correlations between improvement in ACT score and improvement in ACQ score [8][9][10][11][12][13], with five of the publications assessing the statistical significance of the correlations. All five of these reports found statistically significant Number of asthma exacerbations 10 2 26,27 (2) 26,27 8 17,22,23,28-32 (7) 22,23,[28][29][30][31][32] Lung function 17 8 3,15,27,33-37 (5 b ) 3,34-37 9 11,13,18,38-43 (7 b ) 11,13,[38][39][40]42,43 General HRQoL 7 0 (0) 7 [49][50][51][52][53][54][55] (5 b ) 49,50,[52][53][54] Asthma-related QoL 7 5 28,34,[44][45][46] (5) 28,34,44-46 2 47,48 (2) 47,48 Sleep quality 6 2 45,56 (2) 45,56 5 [56][57]…”

“…A total of seven articles reported HRQoL in asthma patients [28,34,[44][45][46][47][48], all of which showed strong positive relationships between improvement in ACT score and improvement in Asthma Quality of Life Questionnaire (AQLQ) score (Table 1). All seven studies published statistically significant results, five from correlation tests [28,34,[44][45][46], and two derived from regression analyses [47,48].…”

“…In total, six articles reported on aspects of sleep quality, including instruments that measured daytime sleepiness and obstructive sleep apnea [45,[58][59][60][61][62]; three of these studies utilized multiple sleep quality instruments (Table 1) [58,60,62].…”

“…Of the four studies using the Pittsburgh Sleep Quality Index (PSQI) [45,58,60,62], two reported notable, statistically significant correlations between improvement in ACT score and improvement in sleep quality (r = − 0.315, p < 0.001 and r = − 0.620, p < 0.001, respectively) [45,58]. Additionally, Lv et al [60] found that poor sleep quality, assessed by PSQI, was related to lower ACT score using regression analyses (β = − 0.87, p = 0.045).…”

Dental/ Periodontal Durum Ve Hasta Tarafindan Beyan Edilmiş Reflü Semptom İndeksi Skorlari Arasindaki Olasi İlişkinin Değerlendirilmesi. Önçalişma

“…Different reflux symptom characteristics and history were evaluated with previously studied version of selfreported RSI questionnaire (17) that was used in clinical studies involving Turkish population (20,(24)(25)(26) (30,31). GER defines the reflux of gastrointestinal secretions mainly the gastric acid into esophagus and even into the oral cavity.…”