Reference values for 34 frequently used laboratory tests in 80-year-old men and women

Helmersson‐Karlqvist, Johanna; Ridefelt, Peter; Lind, Lars; Larsson, Anders

doi:10.1016/j.maturitas.2016.07.015

Cited by 22 publications

(41 citation statements)

References 15 publications

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“…Patients who refused to participate were excluded. Based on the long-term care insurance (LTCI) law in Japan, the LTCI applicant is assigned to one of the levels of care required (certified support level of 1-2 or care level of [1][2][3][4][5] or to non-certified. 2 Patients who were certified at the LTCI support level and who did not need the service were regarded as physically independent.…”

Section: Methodsmentioning

confidence: 99%

“…Aging is associated with a decline in overall bodily maintenance and health . Although laboratory tests are frequently carried out in daily geriatric practice, the reference ranges for these tests are generally based on healthy individuals aged 20–50 years . Because the criteria for defining a “healthy” population of advanced‐age individuals vary, it might be difficult to establish reference values for these older individuals.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Although laboratory tests are frequently carried out in daily geriatric practice, the reference ranges for these tests are generally based on healthy individuals aged 20-50 years. 3 Because the criteria for defining a "healthy" population of advanced-age individuals vary, it might be difficult to establish reference values for these older individuals. Clarification of the differences in blood tests between younger and older adult patients would contribute to accurate interpretation of laboratory results, and proper management of patients in clinical and research settings.…”

Section: Introductionmentioning

confidence: 99%

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Reference range of clinical blood tests in physically independent patients of advanced age with groin hernia in a Japanese hospital

Matsuo

Tazawa

2019

Geriatrics Gerontology Int

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Aim The present study was carried out to determine the reference ranges of 43 frequently used blood tests in daily practice for physically independent patients of advanced age. Methods We identified all patients aged ≥20 years who underwent groin hernia repair at Itoigawa General Hospital in Niigata, Japan. The patients’ characteristics, preoperative data and prescribed medications were obtained by reviewing the electronic medical records. Results Of 284 patients, 266 with independence in activities of daily life were included in the present study: 72 were assigned to the younger adult group (age 20–64 years), 86 were assigned to the older adult group (age 65–74 years) and 108 were assigned to the advanced age group (age ≥75 years). Patients in the advanced age group had a lower body mass index, less alcohol consumption, more hypertension, lower respiratory function and higher frequency of multidrug therapy. The multiple regression analysis showed significant differences in albumin, gamma‐glutamyl transpeptidase, cholinesterase, estimated glomerular filtration rate, uric acid, triglyceride, calcium, phosphate, magnesium and peripheral blood cell counts between the advanced age group and the other two age groups. Conclusions We identified age‐dependent changes in several blood tests among physically independent adults. These results will help to guide accurate interpretation of laboratory results and properly manage patients in geriatric medicine. Geriatr Gerontol Int 2019; 19: 780–785.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reference range of clinical blood tests in physically independent patients of advanced age with groin hernia in a Japanese hospital

Matsuo

Tazawa

2019

Geriatrics Gerontology Int

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“…The current use of RIs from adults aged 20‐50 is not appropriate for geriatric population any more. Moreover, this study got the obviously different RIs from the study of Johanna et al who investigated the Reference values in 80‐year‐old and the study of Lena et al who built Reference Intervals in 70‐year‐old males and females. The different level of TBIL, DBIL, UR, and UA may be mainly associated with different reference population, as these two studies were completed in Sweden Population.…”

Section: Discussionmentioning

confidence: 97%

Reference intervals for serum bilirubin, urea, and uric acid in healthy Chinese geriatric population

Yao

Jiang

Tang

et al. 2017

Clinical Laboratory Analysis

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“…The normal range of albumin is 5.49 · 10 5 nM to 7.20 · 10 5 nM [46]. However, the level is frequently decreased in elderly people [47].…”

Section: Steroid and Transport Protein Concentrationsmentioning

confidence: 98%

Analysis and validation of a new extended method for estimating plasma free cortisol including neutrophil elastase and competition from other steroids

Gudmand-Hoeyer

Ottesen

2018

The Journal of Steroid Biochemistry and Molecular Biology

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A non-linear mechanistic model for the distribution of cortisol in plasma on free and bound forms is proposed. The influence of progesterone, testosterone and neutrophil elastase on the cortisol distribution in the blood is investigated. The activity of neutrophil elastase is directly included in the model with the concentration of elastase and the kinetic constants describing the activity of elastase collected in one single input variable. The model is very sensitive towards this input variable and fits data excellently, when it is allowed to be subject specific. The analysis shows that steroids such as testosterone with low affinity for corticosteroid-binding globulin (CBG) do not significantly influence the concentration of free cortisol. Progesterone has a high affinity for CBG, but low plasma concentrations compared to cortisol. Contrary to expectations, progesterone is shown to impact the distribution of cortisol in plasma both under circumstances with high levels as seen in pregnancy and during the normal menstrual cycle of women. Comparing the predictions of our model with predictions made with the equilibrium models by Coolens et al. [1], Dorin et al. [2] and Nguyen et al. [3] shows that the models differ considerably not only in their predictions for free cortisol, but also for cortisol on bound forms; i.e. bound to albumin, intact CBG and elastase-cleaved CBG. Disregarding some of the smallest terms of the model equations a reduced version of the model in form of a fourth order polynomial equation is obtained. The reduced version of the model performs almost identically to the full version and serves as a new formula for calculating the plasma free cortisol concentration.

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Reference values for 34 frequently used laboratory tests in 80-year-old men and women

Cited by 22 publications

References 15 publications

Reference range of clinical blood tests in physically independent patients of advanced age with groin hernia in a Japanese hospital

Reference range of clinical blood tests in physically independent patients of advanced age with groin hernia in a Japanese hospital

Reference intervals for serum bilirubin, urea, and uric acid in healthy Chinese geriatric population

Analysis and validation of a new extended method for estimating plasma free cortisol including neutrophil elastase and competition from other steroids

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