Reference Intervals for Serum Creatinine Concentrations: Assessment of Available Data for Global Application

Ceriotti, Ferruccio; Boyd, James C.; Klein, Gerhard; Henny, Joseph; Queraltó, Jenny Moix; Kairisto, Veli; Panteghini, Mauro; Limits, Decision

doi:10.1373/clinchem.2007.099648

Cited by 196 publications

(139 citation statements)

References 30 publications

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“…The need for standardization of cystatin C, similar to the IDMS traceability of serum creatinine It should be highlighted that problems due to lack of standardization of cystatin C lead to similar problems as was highlighted above with regards to serum creatinine and the need for IDMS traceability (45) . Results obtained with the two main assays that are commercially available, namely the DAKO kit (turbidimetric, PETIA) and the Siemens Healthcare assay (nephelometric, PENIA), can be quite different, as recently demonstrated with the publication of reference intervals for healthy term and preterm infants.…”

Section: Chromementioning

confidence: 98%

“…This will make the validation of older methods to estimate GFR based on serum creatinine, measured by different techniques, subject to debate. Only more recently, the traceability of the creatinine measurements to higher-order reference methods [isotope dilution-mass spectrometry (IDMS) reference method] improved accuracy of creatinine measurements (45) . This paper established improved pediatric reference intervals that may be adopted by any laboratory serving a similar population (predominantly Caucasian).…”

Section: Limitations Of Serum Creatinine As Endogenous Marker Of Gfrmentioning

confidence: 99%

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The usefulness of cystatin C and related formulae in pediatrics

Filler

Huang

Yasin

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Serum creatinine does not share the properties of an ideal marker of glomerular fi ltration rate (GFR) like inulin, but continues to be the most widely used endogenous marker of GFR. In the search of a better biomarker of GFR, the small molecular weight protein cystatin C has been introduced with features more similar to that of inulin, such as constant production and no non-renal elimination. However, it has not enjoyed widespread use despite its signifi cantly improved diagnostic performance in the detection of impaired GFR and its independence of body composition. A variety of formulae based on either cystatin C or creatinine or both have been developed to estimate GFR. We summarize the currently used methods of GFR measurement, their limitations and analytical errors. The review also summarizes the history, features and the feasibility of cystatin C measurements as well as the most widely used formulae for the estimation of GFR in children. The diagnostic performance of the cystatin C derived eGFR formulae at various levels of GFR is also discussed. An eGFR formula derived from pooled studies analyzing both creatinine and cystatin C, and using a biology-based mathematical approach may be advantageous.

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Section: Chromementioning

confidence: 98%

Section: Limitations Of Serum Creatinine As Endogenous Marker Of Gfrmentioning

confidence: 99%

The usefulness of cystatin C and related formulae in pediatrics

Filler

Huang

Yasin

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…While establishing common reference intervals, the first step in this process is willingness among laboratories towards one goal and the development of an organizational structure to provide leadership (62)(63)(64)(65)(66)(67). Whenever a lab introduces new methodology for particular analyte it is suggested to review and revalidate the reference interval as uncritical transfer of old reference interval amounts to bad practice.…”

Section: Transference Acceptance Of Common Reference Intervals and Rmentioning

confidence: 99%

Whether western normative laboratory values used for clinical diagnosis are applicable to Indian population? An overview on reference interval

Malati

2009

Indian J Clin Biochem

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“…Pediatric reference intervals for industrialized countries 17,[20][21][22] and, in the case of ALT, bilirubin, creatinine, sTFR, and CRP for African children, 1,4,23 were obtained from published data. For the data that contained different age-specific reference intervals, 17 we selected comparable age ranges from the children in this study to allow direct comparison.…”

Section: Methodsmentioning

confidence: 99%

Reference Intervals for Common Laboratory Tests in Melanesian Children

Manning¹,

Laman²,

Townsend³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Pediatric reference intervals for biochemical tests are often derived from studies in Western countries and may not be applicable to the developing world. No such intervals exist for Melanesian populations. The aim of this study was to provide specific reference intervals for children from Papua New Guinea (PNG). We assayed plasma from 327 healthy Melanesian children living in Madang Province for common biochemical and hematological analytes. We used well-validated commercially available assay methodology. Compared with reference intervals from children from Western countries and/or African children, there were substantial differences in hemoglobin, soluble transferrin receptor, ferritin, calcium, phosphate, and C-reactive protein. Differences in the upper limits of reference intervals for bilirubin and alanine aminotransferase were also observed. Available reference intervals from Western and African countries may be inappropriate in PNG and other Melanesian countries. This has implications for clinical care and safety monitoring in pharmaceutical intervention trials and vaccine studies.

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Reference Intervals for Serum Creatinine Concentrations: Assessment of Available Data for Global Application

Cited by 196 publications

References 30 publications

The usefulness of cystatin C and related formulae in pediatrics

The usefulness of cystatin C and related formulae in pediatrics

Whether western normative laboratory values used for clinical diagnosis are applicable to Indian population? An overview on reference interval

Reference Intervals for Common Laboratory Tests in Melanesian Children

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