Reference field specification and preliminary beam selection strategy for accelerator-based GCR simulation

Slaba, Tony C.; Blattnig, Steve R.; Norbury, John W.; Rusek, A.; Tessa, Chiara La

doi:10.1016/j.lssr.2016.01.001

Cited by 60 publications

(40 citation statements)

References 24 publications

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“…Several strategies have been proposed to use the GCR simulator for reproducing space radiation fields in different scenarios. Details can be found in (Slaba et al, 2016;Kim et al, 2015) while a general review of the project including its impact on the NSRL scientific program is presented in (Kim et al, 2015).…”

Section: Spe and Gcr Simulatorsmentioning

confidence: 99%

“…While the GCRSim offers the possibility to deliver a custom mix of ions and energies within the available choices, two reference fields have been defined (Slaba et al, 2016). One approach (referred to as external field) approximates the external, free space GCR spectrum with discrete ions and energy beams and deliver them onto a shielding material placed in front of the sample.…”

Section: Spe and Gcr Simulatorsmentioning

confidence: 99%

“…An alternative to the external field, called local tissue field approach, is to deliver a mix of beams that directly reproduce the dose profile in a representative tissue of an astronaut behind a shielding. Details on how to reproduce the external and local tissue fields are described in (Slaba et al, 2016). An example of the dose profile in a mouse-like phantom exposed to isotropic radiation and corresponding LET spectrum necessary to deliver it are shown in Figure 5.…”

Section: Spe and Gcr Simulatorsmentioning

confidence: 99%

“…The latter is calculated using a continuous reference field (line) and discrete beams (dots). Figure taken from (Slaba et al, 2016).…”

Section: Ion Species and Energymentioning

confidence: 99%

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The recent progress and future of oxygen reduction reaction catalysis: A review

Stacy

Regmi

Leonard

et al. 2017

Renewable and Sustainable Energy Reviews

315

202

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The NASA Space Radiation Laboratory (NSRL) is a multidisciplinary center for space radiation research funded by NASA and located at the Brookhaven National Laboratory (BNL), Upton NY. Operational since 2003, the scope of NSRL is to provide ion beams in support of the NASA Humans in Space program in radiobiology, physics and engineering to measure the risk and ameliorate the effect of radiation in space. Recently, it has also been recognized as the only facility in the U.S. currently capable of contributing to heavy ion radiotherapy research. This work contains a general overview of NSRL structure, capabilities and operation.

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Section: Spe and Gcr Simulatorsmentioning

confidence: 99%

Section: Spe and Gcr Simulatorsmentioning

confidence: 99%

Section: Spe and Gcr Simulatorsmentioning

confidence: 99%

“…The latter is calculated using a continuous reference field (line) and discrete beams (dots). Figure taken from (Slaba et al, 2016).…”

Section: Ion Species and Energymentioning

confidence: 99%

See 2 more Smart Citations

The recent progress and future of oxygen reduction reaction catalysis: A review

Stacy

Regmi

Leonard

et al. 2017

Renewable and Sustainable Energy Reviews

315

202

View full text Add to dashboard Cite

show abstract

“…GCRs consist of 85% low LET protons, 14% helium ions, and 1% HZE particles (Bourdarie and Xapsos 2008). However, HZE particles such as oxygen and iron, will make up 21% of the estimated ionizing dose equivalent from GCR exposure during deep space travel (Slaba, et al 2015). The estimated ionizing dose equivalent of a three-year Mars mission is 40 cGy (1.07 Sv absorbed dose) (Barcellus-Hoff, et al 2015, Cucinotta and Durante 2006).…”

Section: Introductionmentioning

confidence: 99%

Very low doses of heavy oxygen ion radiation induce premature ovarian failure

et al. 2017

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Astronauts are exposed to charged particles during space travel, and charged particles are also used for cancer radiotherapy. Premature ovarian failure is a well-known side-effect of conventional, low linear energy transfer (LET) cancer radiotherapy, but little is known about the effects of high LET charged particles on the ovary. We hypothesized that lower LET (16.5 keV/µm) oxygen particles would be less damaging to the ovary than we previously found for iron (LET=179 keV/µm). Adult female mice were irradiated with 0, 5, 30, or 50 cGy oxygen ions or 50 cGy oxygen plus dietary supplementation with the antioxidant alpha lipoic acid (ALA). 6h after irradiation, percentages of ovarian follicles immunopositive for γH2AX, a marker of DNA double strand breaks, 4-HNE, a marker of oxidative lipid damage, and PUMA, a proapoptotic BCL-2 family protein, were dose-dependently increased in irradiated mice compared to controls. One week after irradiation, numbers of primordial, primary, and secondary follicles per ovary were dose-dependently decreased, with complete absence of follicles in the 50 cGy groups. The ED50 for primordial follicle destruction was 4.6 cGy for oxygen compared to 27.5 cGy for iron in our previous study. Serum FSH and LH concentrations were significantly elevated in 50 cGy groups at 8wk. Supplementation with ALA mitigated the early effects, but not the ultimate depletion of ovarian follicles. In conclusion, oxygen charged particles are even more potent inducers of ovarian follicle depletion than charged iron particles, raising concern for premature ovarian failure in astronauts exposed to both particles during space travel.

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High-Resolution Electron Energy Loss Spectroscopy: Absolute Cross Section Measurements for Low Energy Electron Scattering from Biomolecules

Lemelin

Sanche

2019

Radiation in Bioanalysis

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Reference field specification and preliminary beam selection strategy for accelerator-based GCR simulation

Cited by 60 publications

References 24 publications

The recent progress and future of oxygen reduction reaction catalysis: A review

The recent progress and future of oxygen reduction reaction catalysis: A review

Very low doses of heavy oxygen ion radiation induce premature ovarian failure

High-Resolution Electron Energy Loss Spectroscopy: Absolute Cross Section Measurements for Low Energy Electron Scattering from Biomolecules

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