J. Clin. Lab. Anal.
 1999
DOI: 10.1002/(sici)1098-2825(1999)13:6<273::aid-jcla4>3.0.co;2-x
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Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: A practical, simple and clinically relevant approach in a large cohort

Robert F. Ritchie
1
,
Glenn E. Palomaki
2
,
Louis M. Neveux
3
et al.
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Cited by 256 publications

(191 citation statements)
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“…Notably, a significant inverse correlation was observed between CRP and albumin levels (rho=-0.27, p<0.0001) as shown in Figure 11B, highlighting the divergent association of a "positive" and a "negative" acute-phase proteins (431). Our analysis showed a positive correlation between CRP and PTX3 levels (rho=0.20, p=0.0004) when pooled data were analyzed (Figure 11A), which is consistent with a previous report (395).…”
Section: Resultssupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Notably, a significant inverse correlation was observed between CRP and albumin levels (rho=-0.27, p<0.0001) as shown in Figure 11B, highlighting the divergent association of a "positive" and a "negative" acute-phase proteins (431). Our analysis showed a positive correlation between CRP and PTX3 levels (rho=0.20, p=0.0004) when pooled data were analyzed (Figure 11A), which is consistent with a previous report (395).…”
Section: Resultssupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…its synthesis decreases after IL-6 exposure. These findings are in accordance with the classic literature, which refers to albumin as being a negative acute-phase protein (Ritchie et al 1999a , 1999b ). Separate studies have indicated that RLEC in monoculture (without hepatocytes) are unable to secrete albumin (our results; Snykers et al 2007 ).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Serotransferrin is a negative, acute-phase protein involved in physiological changes that cause various effects, including tissue damage, infections, and immune disorders, and reduces chronic inflammation and malignant growth [ 58 ]. Serotransferrin protein levels were significantly lower in patients ovarian and other gynaecological cancers [ 59 , 60 ] and during inflammation [ 61 ], which is consistent with the findings of other previous studies. TTRs are proteins that bind to thyroid hormones and globules and transport thyroid hormones in the blood.…”
Section: Discussionsupporting
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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