Reference change values: how useful are they?

Pediatric Within-Day Biological Variation and Quality Specifications for 38 Biochemical Markers in the CALIPER Cohort

“…Of particular interest, the reduction of II for iron to 0.38 suggests further investigation of the utility of an iron reference interval for clinical decision-making in a pediatric population. Although it may be appropriate to further examine the usefulness of population-based reference intervals in cases in which the II falls below 0.6, it is also important to consider the clinical context in which the analyte is likely to be used (25 ). In many cases, a pathological state would result in a dramatic increase in analyte concentration that would clearly fall outside of the established reference interval.…”

Three of 7 Hemoglobin A1c Point-of-Care Instruments Do Not Meet Generally Accepted Analytical Performance Criteria

“…where CV a is the analytical CV and CV wp is the intraindividual or biological (within-person) CV (CV wp ) (14,15 ).…”

Cardiac Biomarkers in End-Stage Renal Disease

“…The analytical variation is described by the CV A and the individual (biological) variation by the CV I (Omar, van der Watt, & Pillay, 2008). To date, there are only a few studies that investigated the RCV values for cTnT (Vasile, Saenger, Kroning, & Jaffe, 2010) and cTnI (Wu, Lu, Todd, Moecks, & Wians, 2009) in healthy subjects and more studies are needed to examine the strengths and weaknesses of using RCV values for the diagnosis of AMI.…”