Refeeding syndrome: a clinical review

Ormerod, Clare; Farrer, K.; Harper, Lindsay; Lal, Simon

doi:10.12968/hmed.2010.71.12.686

Cited by 16 publications

(11 citation statements)

References 25 publications

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“…Refeeding in AN with serious or fatal complications is anecdotally recognized (20, 21, 22, 23, 24, 25). RFS is defined as electrolyte disturbances, principally low serum concentrations of intracellular ions such as phosphate, magnesium and potassium (26, 27). The electrolyte movements from the extracellular to the intracellular space is believed to be caused by insulin spikes (28).…”

Section: The Refeeding Syndromementioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update

Støving

2019

European Journal of Endocrinology

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Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical settings such as inpatient intensive re-nutrition or in a setting with somatic comorbidity. Electrolyte levels must be closely monitored during the refeeding process, and the need for weight gain must be balanced against potentially fatal refeeding complications. An important focus of clinical research should be to identify biomarkers associated with different stages of weight loss and re-nutrition combined with psychometric data. Besides well-established peripheral endocrine actions, several hormones also are released directly to different brain areas, where they may exert behavioral and psychogenic actions that could offer therapeutic targets. We need reliable biomarkers for predicting outcome and to ensure safe re-nutrition, however, first of all we need them to explore the metabolism in anorexia nervosa to open new avenues with therapeutic targets. A breakthrough in our understanding and treatment of this whimsical disease remains. Considering this, the aim of the present review is to provide an updated overview of the many endocrine changes in a clinical perspective.

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Section: The Refeeding Syndromementioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update

Støving

2019

European Journal of Endocrinology

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“…Its first clear depictions were in inmates of Second World War concentration camps who had been rendered grossly malnourished through chronic starvation. Intentionally generous oral refeeding led to unexpected and catastrophic metabolic crises with many deaths, preceded by cardiac failure and neurological manifestations (Ormerod et al 2010;Stanga et al 2008). RFS typically (more than two thirds of cases) occurs within 3 days after the reintroduction of nutrition (by any route) but can occur within 24 h and may also be deferred for more than a week if incomplete preventative measures are taken.…”

Section: 5mentioning

confidence: 99%

Critical Care for Anorexia Nervosa

Robinson¹,

Nicholls²

2015

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“…Thiamine deficiency can deteriorate congestive cardiac failure in the so-called wet beriberi (Francini-Pesenti et al 2009) or produce Korsakoff's syndrome characterized by anterograde and retrograde amnesia (defect in learning and loss of memory, respectively), with normal immediate memory, though short-term memory is impaired (Zubaran et al 1997), and confabulation (Ormerod et al 2010).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Specialized teams of nutritional support can guide and educate other health professionals in the prevention, diagnosis, and treatment of RS (Hearing 2004;Ormerod et al 2010;Viana et al 2012). …”

Section: Preventionmentioning

confidence: 99%