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Cited by 26 publications
(13 citation statements)
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References 33 publications
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“…Polymeric micelles are usually chosen as nanocarriers for hydrophobic cargoes for cancer diagnosis and therapy. However, their instability during circulation in the bloodstream is of great concern because micelles may dissociate if their concentration is diluted to below the critical micelle concentration (CMC), which results in the unexpected leakage of cargoes and subsequent side effects . To date, only one micellar NP (Estrasorb) has been approved by the FDA for clinical therapy .…”
Section: Stimuli‐responsive Drug‐release Nanosystemsmentioning
confidence: 99%
See 1 more Smart Citation
“…Polymeric micelles are usually chosen as nanocarriers for hydrophobic cargoes for cancer diagnosis and therapy. However, their instability during circulation in the bloodstream is of great concern because micelles may dissociate if their concentration is diluted to below the critical micelle concentration (CMC), which results in the unexpected leakage of cargoes and subsequent side effects . To date, only one micellar NP (Estrasorb) has been approved by the FDA for clinical therapy .…”
Section: Stimuli‐responsive Drug‐release Nanosystemsmentioning
confidence: 99%
“…Then, H 2 O 2 was added to the micellar solution to initiate the crosslinking reaction of hanging sulfhydryl groups of the P(AGE‐SH) block (Scheme A). In vitro DOX release profiles demonstrated that the crosslinked micelles remained stable under dilute conditions, but rapidly released the loaded drugs in the presence of GSH . Deng et al.…”
Section: Stimuli‐responsive Drug‐release Nanosystemsmentioning
confidence: 99%
“…The amphiphilic copolymer of PCL modified by PEG could enhance the hydrophilicity of PCL, prevent protein adsorption, and easily go through physiological barrier. [ 22,23 ] The unique structure of star‐block PCL–PEG copolymer allows it exhibiting many unique properties, such as lower solution viscosity in dilute solutions, lower critical micelle concentration (CMC), smaller hydrodynamic diameters, and narrower size distributions. [ 24–26 ] These properties of PCL–PEG copolymers can enhance their stability and long‐term circulation in the blood.…”
Section: Introductionmentioning
confidence: 99%
“…Until now, light, pH, temperature, or reactive oxygen species could be successfully applied as triggers to guide the anticancer drug release . It is worth mentioned that redox responsive materials with thiol or disulfide functional groups have become popular in designing controllable drug release systems, because ROS is an important biological parameter indicating many disease and cellular redox status .…”
Section: Introductionmentioning
confidence: 99%