2000
DOI: 10.1136/bmj.321.7275.1493
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Abstract: Objectives To obtain reliable estimates of the effects of neuraxial blockade with epidural or spinal anaesthesia on postoperative morbidity and mortality. Design Systematic review of all trials with randomisation to intraoperative neuraxial blockade or not.

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Cited by 1,953 publications
(1,059 citation statements)
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References 146 publications
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“…It is likely complications of bleeding contributed to the increased mortality. Furthermore, bleeding and risk of transfusion are less with regional compared with general anesthesia [46], especially if hypotensive epidural anesthesia is used [21].…”
Section: Discussionmentioning
confidence: 99%
“…It is likely complications of bleeding contributed to the increased mortality. Furthermore, bleeding and risk of transfusion are less with regional compared with general anesthesia [46], especially if hypotensive epidural anesthesia is used [21].…”
Section: Discussionmentioning
confidence: 99%
“…Apart from optimal pain control, neuraxial blockade has anticatabolic effects that may contribute to better outcome. 117 Epidural and intrathecal administration of local anesthetics prevents or blunts the neuroendocrine stress response, which results in improved insulin sensitivity with a positive influence on glucose and protein catabolism. 118 By attenuating insulin resistance and facilitating exogenous glucose utilization, neuraxial techniques reduce the amount of energy that is required to maintain protein balance.…”
Section: Neuraxial Anesthesiamentioning
confidence: 99%
“…2 This, in turn, may be attributable to the reduction in surgical stress response that regional anesthesia provides by blocking nociceptive afferent inputs. 3 Allogeneic blood transfusion is known to decrease cancer survival, 4,5 and regional anesthesia reduces the risk of such transfusions. Our group previously demonstrated that the use of a combined general/epidural hypotensive anesthesia technique during radical prostate surgery resulted in less need for allogeneic blood.…”
Section: Résumémentioning
confidence: 99%