Reduction of Plasma 24S-Hydroxycholesterol (Cerebrosterol) Levels Using High-Dosage Simvastatin in Patients With Hypercholesterolemia

Abstract

The greater reduction of plasma concentrations of 24S-hydroxycholesterol compared with cholesterol indicates that simvastatin in a dosage of 80 mg/d reduces cholesterol turnover in the brain. The present results might describe a possible mechanism of how long-term treatment with statins could reduce the incidence of Alzheimer disease.

Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

“…To the best of our knowledge, there were no reports that evaluated these associations using a covariance structure analysis. In this analysis, statin usage not only positively correlated with "cholesterol absorption", but also with "cholesterol synthesis", contrary to some previous reports that demonstrated reductions in circulating oxysterols even with short-term statin treatment [31,32]. The reason for this discrepancy could be that the subjects in this study were hypercholesterolemic patients with elevated cholesterol synthesis, which led to a statin usage.…”

Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

“…To the best of our knowledge, there were no reports that evaluated these associations using a covariance structure analysis. In this analysis, statin usage not only positively correlated with "cholesterol absorption", but also with "cholesterol synthesis", contrary to some previous reports that demonstrated reductions in circulating oxysterols even with short-term statin treatment [31,32]. The reason for this discrepancy could be that the subjects in this study were hypercholesterolemic patients with elevated cholesterol synthesis, which led to a statin usage.…”

The Effect of Simvastatin Treatment on the Amyloid Precursor Protein and Brain Cholesterol Metabolism in Patients with Alzheimer’s Disease

“…Our results are in agreement with earlier studies [13,44] , where a signifi cant reduction in CSF levels of lathosterol was observed. Also in agreement with earlier results [23] , we found a significant reduction in the plasma level of 27-OH-Chol, while the CSF levels were nonsignifi cantly reduced (table 2 ). 27-OH-Chol is mainly produced in the periphery, where cholesterol is converted into 27-OH-Chol, and together, reduced CSF and plasma levels of lathosterol and reduced plasma levels of 27-OH-Chol indicate that statin treatment lowers the cholesterol synthesis in the periphery as well as in the central nervous system.…”

Cognitive Function Assessment in Patients on Moderate- or High-Intensity Statin Therapy

“…It appears to be the reason why atorvastatin and simvastatin have higher association with non-hepatocytic adverse effects, such as cognitive impairment, compared to all other lipophilic statins [51,54]. Our findings of higher association of cognitive impairment with lipophilic atorvastatin were aligned with the other studies that have demonstrated higher association and severity of cognitive impairment with lipophilic statins compared with hydrophilic statins [11,21,46,[59][60][61][62].…”

Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

“…To the best of our knowledge, there were no reports that evaluated these associations using a covariance structure analysis. In this analysis, statin usage not only positively correlated with "cholesterol absorption", but also with "cholesterol synthesis", contrary to some previous reports that demonstrated reductions in circulating oxysterols even with short-term statin treatment [31,32]. The reason for this discrepancy could be that the subjects in this study were hypercholesterolemic patients with elevated cholesterol synthesis, which led to a statin usage.…”

The Effect of Simvastatin Treatment on the Amyloid Precursor Protein and Brain Cholesterol Metabolism in Patients with Alzheimer’s Disease

“…Our results are in agreement with earlier studies [13,44] , where a signifi cant reduction in CSF levels of lathosterol was observed. Also in agreement with earlier results [23] , we found a significant reduction in the plasma level of 27-OH-Chol, while the CSF levels were nonsignifi cantly reduced (table 2 ). 27-OH-Chol is mainly produced in the periphery, where cholesterol is converted into 27-OH-Chol, and together, reduced CSF and plasma levels of lathosterol and reduced plasma levels of 27-OH-Chol indicate that statin treatment lowers the cholesterol synthesis in the periphery as well as in the central nervous system.…”

Cognitive Function Assessment in Patients on Moderate- or High-Intensity Statin Therapy

“…It appears to be the reason why atorvastatin and simvastatin have higher association with non-hepatocytic adverse effects, such as cognitive impairment, compared to all other lipophilic statins [51,54]. Our findings of higher association of cognitive impairment with lipophilic atorvastatin were aligned with the other studies that have demonstrated higher association and severity of cognitive impairment with lipophilic statins compared with hydrophilic statins [11,21,46,[59][60][61][62].…”

Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

“…To the best of our knowledge, there were no reports that evaluated these associations using a covariance structure analysis. In this analysis, statin usage not only positively correlated with "cholesterol absorption", but also with "cholesterol synthesis", contrary to some previous reports that demonstrated reductions in circulating oxysterols even with short-term statin treatment [31,32]. The reason for this discrepancy could be that the subjects in this study were hypercholesterolemic patients with elevated cholesterol synthesis, which led to a statin usage.…”

The Effect of Simvastatin Treatment on the Amyloid Precursor Protein and Brain Cholesterol Metabolism in Patients with Alzheimer’s Disease

“…Our results are in agreement with earlier studies [13,44] , where a signifi cant reduction in CSF levels of lathosterol was observed. Also in agreement with earlier results [23] , we found a significant reduction in the plasma level of 27-OH-Chol, while the CSF levels were nonsignifi cantly reduced (table 2 ). 27-OH-Chol is mainly produced in the periphery, where cholesterol is converted into 27-OH-Chol, and together, reduced CSF and plasma levels of lathosterol and reduced plasma levels of 27-OH-Chol indicate that statin treatment lowers the cholesterol synthesis in the periphery as well as in the central nervous system.…”

Cognitive Function Assessment in Patients on Moderate- or High-Intensity Statin Therapy

“…It appears to be the reason why atorvastatin and simvastatin have higher association with non-hepatocytic adverse effects, such as cognitive impairment, compared to all other lipophilic statins [51,54]. Our findings of higher association of cognitive impairment with lipophilic atorvastatin were aligned with the other studies that have demonstrated higher association and severity of cognitive impairment with lipophilic statins compared with hydrophilic statins [11,21,46,[59][60][61][62].…”