Biochemical Pharmacology volume 77, issue 1, P134-140 2009 DOI: 10.1016/j.bcp.2008.09.022 View full text
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Renee J. Krause, Adnan A. Elfarra

Abstract: AbstractSeleno-L-methionine (SeMet) can be oxidized to L-methionine selenoxide (MetSeO) by flavincontaining monooxygenase 3 (FMO3) and rat liver microsomes in the presence of NADPH. MetSeO can be reduced by GSH to yield SeMet and GSSG. In the present study, the potential reduction of MetSeO to SeMet by other cellular components and antioxidants was investigated. Besides GSH, other thiols (L-cysteine, or N-acetyl-L-cysteine) and antioxidants (ascorbic acid and methimazole) also reduced MetSeO to SeMet. This r…

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