Reduction of hibernation bout duration by intraventricular infusion of met-enkephalin

Beckman, Alexander L.; Llados-Eckman, Carmen; Stanton, Toni L.

doi:10.1016/0006-8993(92)91357-k

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…Perhaps, most interestingly, we observed an increase in select hypothalamic opioid peptides (from both PENK and PDYN) during IBA relative to torpor, suggesting that these peptides may play important roles during these brief periods of activity during the hibernation season. These results are consistent with prior studies suggesting the involvement of opioid peptides and their receptors during hibernation and hibernation-like phenotypes ,,, and demonstrating that opioid peptides can reduce the duration of torpor bouts . Importantly, delta opioid receptor agonists have been shown to provide neuroprotection against ischemia and reperfusion injury, − suggesting that the increase in endogenous opioid peptides during IBA may be playing a neuroprotective role during the dramatic change in physiology.…”

Section: Discussionsupporting

confidence: 89%

“…These results are consistent with prior studies suggesting the involvement of opioid peptides and their receptors during hibernation and hibernation-like phenotypes 28,29,58,59 and demonstrating that opioid peptides can reduce the duration of torpor bouts. 60 Importantly, delta opioid receptor agonists have been shown to provide neuroprotection against ischemia and reperfusion injury, 61−64 suggesting that the increase in endogenous opioid peptides during IBA may be playing a neuroprotective role during the dramatic change in physiology.…”

Section: ■ Discussionmentioning

confidence: 99%

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Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal

Mousavi

Qiu

Andrews

et al. 2023

ACS Chem. Neurosci.

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During the winter, hibernating mammals undergo extreme changes in physiology, which allow them to survive several months without access to food. These animals enter a state of torpor, which is characterized by decreased metabolism, near-freezing body temperatures, and a dramatically reduced heart rate. The neurochemical basis of this regulation is largely unknown. Based on prior evidence suggesting that the peptide-rich hypothalamus plays critical roles in hibernation, we hypothesized that changes in specific cell–cell signaling peptides (neuropeptides and peptide hormones) underlie physiological changes during torpor/arousal cycles. To test this hypothesis, we used a mass spectrometry-based peptidomics approach to examine seasonal changes of endogenous peptides that occur in the hypothalamus and pituitary of a model hibernating mammal, the thirteen-lined ground squirrel (Ictidomys tridecemlineatus). In the pituitary, we observed changes in several distinct peptide hormones as animals prepared for torpor in October, exited torpor in March, and progressed from spring (March) to fall (August). In the hypothalamus, we observed an overall increase in neuropeptides in October (pre-torpor), a decrease as the animal entered torpor, and an increase in a subset of neuropeptides during normothermic interbout arousals. Notable changes were observed for feeding regulatory peptides, opioid peptides, and several peptides without well-established functions. Overall, our study provides critical insight into changes in endogenous peptides in the hypothalamus and pituitary during mammalian hibernation that were not available from transcriptomic measurements. Understanding the molecular basis of the hibernation phenotype may pave the way for future efforts to employ hibernation-like strategies for organ preservation, combating obesity, and treatment of stroke.

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Section: Discussionsupporting

confidence: 89%

Section: ■ Discussionmentioning

confidence: 99%

Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal

Mousavi

Qiu

Andrews

et al. 2023

ACS Chem. Neurosci.

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Down-regulation in the insulin-like growth factor (IGF) axis during hibernation in the golden-mantled ground squirrel,Spermophilus lateralis: IGF-I and the IGF-binding proteins (IGFBPs)

Schmidt

Kelley

2001

J. Exp. Zool.

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The golden‐mantled ground squirrel, Spermophilus lateralis, undergoes a profound winter hibernation that represents, among other changes, a prolonged period of starvation. In addition to dramatic metabolic and other physiological adaptations during hibernation which serve to reduce fuel energy expenditure, we have hypothesized that there may also be significant changes in the endocrine axis that regulates energetically‐expensive somatic growth. As compared with euthermic, non‐hibernating controls, hibernating S. lateralis were found to have 75%‐reduced serum concentrations of insulin‐like growth factor‐I (IGF‐I; from ∼625 to ∼150 ng/ml in both females and males, P < 0.05). While IGFBP‐3 was the predominant IGFBP in serum of the euthermic controls, its levels were reduced to a similar degree in serum from the hibernating animals. IGFBP‐4 was present at relatively low levels in the euthermic controls, and was reduced to undetectable levels in hibernating animals. Surprisingly, there was no IGFBP detectable in the 30 kDa range in either euthermic or hibernating S. lateralis, suggesting that IGFBP‐1 does not play a role in hibernation‐related changes in the IGF axis. In accordance with these endocrine changes, when serum from hibernating S. lateralis was added to cartilage explant cultures (at a 5% v/v concentration), it exhibited no ability to alter 35S‐proteoglycan synthetic rate, whereas serum from the euthermic squirrels significantly stimulated synthetic activity by 2‐fold. These results suggest that part of hibernation adaptation in S. lateralis includes down‐regulation in the growth‐regulatory IGF axis. J. Exp. Zool. 289:66–73, 2001. © 2001 Wiley‐Liss, Inc.

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Changes in striatal dopamine metabolism during the development of morphine physical dependence in rats: Observations using in vivo microdialysis

et al. 1993

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Reduction of hibernation bout duration by intraventricular infusion of met-enkephalin

Cited by 9 publications

References 23 publications

Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal

Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal

Down-regulation in the insulin-like growth factor (IGF) axis during hibernation in the golden-mantled ground squirrel,Spermophilus lateralis: IGF-I and the IGF-binding proteins (IGFBPs)

Changes in striatal dopamine metabolism during the development of morphine physical dependence in rats: Observations using in vivo microdialysis

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