Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation

Bozzetto, Lutgarda; Costabile, Giuseppina; Luongo, Diomira; Cicala, V; Piantadosi, Chiara; Patti, L.; Cipriano, Paola; Annuzzi, Giovanni; Rivellese, Angela Albarosa

doi:10.1007/s00125-016-4110-5

Cited by 28 publications

(22 citation statements)

References 11 publications

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“…33 Some recent studies 34,35 have shown long-term reduction of HFC and improvement in liver markers despite weight gain after dietary weight loss. Bozzetto et al 13,36 showed that an isocaloric diet enriched in monounsaturated fatty acids results in a reduction in HFC (by increasing fat oxidation), independent of weight change. In addition, the beneficial effect of different dietary strategies has been demonstrated in previous studies suggesting significant reductions in HFC with minor to moderate weight loss, 37 but this was not observed in larger, more recent studies.…”

Section: Discussionmentioning

confidence: 99%

“…11 Diet plays an important role in the accumulation of HFC and VAT. 12 Several short- 6,13 and long-term 14,15 dietary interventions have suggested that Mediterranean and low-carb diets had favorable effects on VAT and HFC accumulation, but also on glycemic status and lipid biomarkers. Others found no differences between HFC changes induced by diets with different amounts of carbohydrate.…”

Section: Introductionmentioning

confidence: 99%

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The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content

Gepner

Shelef

Komy

et al. 2019

Journal of Hepatology

170

146

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content

Gepner

Shelef

Komy

et al. 2019

Journal of Hepatology

170

146

View full text Add to dashboard Cite

show abstract

“…Several studies considered it to be an HC diet if carbohydrate intake is over just 50% of total energy intake [34,35]. We guessed them as moderate carbohydrate diets (50%–54%), which were defined as HC diets in their studies, so we did not include them in this review [34,35]. On the other hand, the above-mentioned studies which were conducted in Asians generally set the standard of an HC diet as a carbohydrate intake over 60% of total energy.…”

Section: Literature About the Effects Of High Carbohydrate On Metamentioning

confidence: 99%

Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes

Jung

Choi

2017

Nutrients

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In patients with type 2 diabetes mellitus (T2DM), whether dietary carbohydrates have beneficial or detrimental effects on cardiometabolic risk factors has drawn attention. Although a high-carbohydrate (HC) diet and a low-carbohydrate (LC) diet have gained popularity for several decades, there is scarce review focusing on the effects of HC diet on glucose, lipids and body weight in patients with T2DM. In this review, we examined recently-published literature on the effects of HC diets on metabolic parameters in T2DM. HC diets are at least as effective as LC diets, leading to significant weight loss and a reduction in plasma glucose, HbA1c and low density lipoprotein-cholesterol (LDL-C) levels. The major concern is that HC diets may raise serum triglyceride levels and reduce high density lipoprotein-cholesterol (HDL-C) levels, increasing the risk of cardiovascular disease. However, these untoward effects were not a persistent consequence and may be ameliorated with the consumption of a low glycemic index (GI)/low glycemic load (GL) and high fiber. Carbohydrate intake should be individualized, and low caloric intake remains a crucial factor to improve insulin sensitivity and reduce body weight; however, an HC diet, rich in fiber and with a low GI/GL, may be recommendable in patients with T2DM.

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“…Although the evidence is rather convincing, the exact mechanism through which MUFA could affect hepatic triglycerides content is not completely clear. In both in vitro and in vivo studies, MUFA have been shown to activate peroxisome proliferator-activated receptor-alfa (PPARα) and PPARγ [ 56 ], increasing lipid oxidation [ 57 , 58 , 59 ] and inhibiting lipogenesis [ 58 , 60 ], thus leading to a reduction in hepatic steatosis ( Figure 2 ). On the other hand, MUFA can promote fatty acid deposition in adipose tissue rather than in the liver, enhancing the clearance of circulating triglyceride rich lipoproteins by lipoprotein lipase [ 61 ].…”

Section: Diet Composition and Non-alcoholic Fatty Liver Disease Inmentioning

confidence: 99%

Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals

et al. 2017

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Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro- or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. We also describe the plausible mechanisms by which different dietary components could modulate liver fat content.

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Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation

Abstract: ClinicalTrials.gov NCT01025856 FUNDING : The study was funded by Ministero Istruzione Università e Ricerca and Italian Minister of Health.

Cited by 28 publications

References 11 publications

The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content

The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content

Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes

Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals

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