C ardiovascular disease (CVD), including heart disease and stroke, is the leading cause of death in the United States, producing an immense health and economic burden. An estimated 92.1 million US adults are diagnosed with at least one type of CVD, and a projected 43.9% of US adults will have some form of CVD by 2030.1 One of the primary reasons for the continued high burden of CVD is the persistent and even increasing degrees of obesity, type 2 diabetes mellitus, and hypertension. To a large extent, these major risk factors are driven by poor nutrition from an increase in the consumption of processed foods high in sodium, refined carbohydrates, and saturated fat. Unfortunately, all US populations do not have the same levels of access to healthy foods, especially in certain socially and economically disadvantaged neighborhoods. Contributors of CVD inequalities include race, ethnicity, social support, culture and language, access to care, and residential environment. These social determinants of health influence overall health and CVD outcomes.
See Article by Kelli et alFood deserts are characterized as areas that lack access to affordable fruits, vegetables, whole grains, low-fat milk, and other foods that make up the full range of a healthy diet, and traditionally described as urban areas in which residents cannot easily reach fresh food options. These neighborhoods are usually comprised of lower income populations, whose residents must rely on unhealthier processed foods from convenience stores, gas stations, and fast-food restaurants, rather than supermarkets and grocery stores, which may provide healthy food choices.In this issue of Circulation: Cardiovascular Quality and Outcomes, Kelli et al 3 analyze the impact of poor access to healthy food in Atlanta, GA area. The authors evaluated multiple metabolic factors, in addition to demographic characteristics, which may be related to diminished healthy food availability. One important aspect of this study is its measurement of novel biomarkers, including high-sensitivity C-reactive protein for chronic inflammation, and glutathione and cystine levels for estimating oxidative stress. The authors also assessed peripheral pulse wave velocities to evaluate arterial stiffness. Despite being surrogate markers, there is a rich literature that justifies the use of these tools to assess CVD risk for patients. [4][5][6][7] Their findings conclude that individuals living in a food desert had a higher prevalence of cardiovascular risk factors, inflammation, oxidative stress, and arterial stiffness. Furthermore, the authors suggest these findings were largely driven by socioeconomic factors. Beyond mere access to healthy foods, this study indicates that CVD risk scores are higher in individuals living in low-income neighborhoods or those with lower personal finances.With the present study in mind, should we no longer consider living in food deserts as a CVD risk factor? One of the shortcomings of the overinterpretation of these results is the fairly small sample size, with ...