Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: A diffusion tensor study using TBSS

Liu, Xiaoyi; Lai, Yunyao; Wang, Xijin; Chuanxi, Hao; Chen, Lei; Zhou, Zhenyu; Yu, Xin; Hong, Nan

doi:10.1016/j.bbr.2013.05.061

Cited by 90 publications

(71 citation statements)

References 87 publications

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“…23 Moreover, a higher FA has been related to interhemispheric transition time measured with event-related potentials (ERP) 45 and quantitative electroencephalography (EEG). 46 Finally, as higher FA has been associated with better functional connectivity between anatomically distant gray matter regions using resting-state fMRI (functional MRI) 35,47,48 and better functional connectivity has been associated with higher cognitive functioning, 49,50 these findings may also extend to the nonphysical realm.…”

Section: Discussionmentioning

confidence: 89%

Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls

Svátková

Mandl

Scheewe

et al. 2015

SCHBUL

103

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It has been shown that learning a new skill leads to structural changes in the brain. However, it is unclear whether it is the acquisition or continuous practicing of the skill that causes this effect and whether brain connectivity of patients with schizophrenia can benefit from such practice. We examined the effect of 6 months exercise on a stationary bicycle on the brain in patients with schizophrenia and healthy controls. Biking is an endemic skill in the Netherlands and thus offers an ideal situation to disentangle the effects of learning vs practice. The 33 participating patients with schizophrenia and 48 healthy individuals were assigned to either one of two conditions, ie, physical exercise or lifeas-usual, balanced for diagnosis. Diffusion tensor imaging brain scans were made prior to and after intervention. We demonstrate that irrespective of diagnosis regular physical exercise of an overlearned skill, such as bicycling, significantly increases the integrity, especially of motor functioning related, white matter fiber tracts whereas life-as-usual leads to a decrease in fiber integrity. Our findings imply that exercise of an overlearned physical skill improves brain connectivity in patients and healthy individuals. This has important implications for understanding the effect of fitness programs on the brain in both healthy subjects and patients with schizophrenia. Moreover, the outcome may even apply to the nonphysical realm.

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Section: Discussionmentioning

confidence: 89%

Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls

Svátková

Mandl

Scheewe

et al. 2015

SCHBUL

103

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“…A voxelbased analysis of medicationnaive patients with chronic schizophre nia compared with healthy controls 49 revealed significant FA reduction in the left ILF in the schizophrenia group, and this white matter disruption was associated with poorer neurocog nitive performance in speed of processing, verbal learning and visual learning tasks. In contrast to the present study, Liu and colleagues 49 found no significant betweengroups differences in RD or AD or in white matter integrity markers of the left ILF and attention/vigilance or working memory. Another study on FEP 50 found that reduced FA in the left ILF correlated with impairment in working memory/attention shifting (TMTB) but not cognitive processing speed (TMTA) or verbal learning and recall (RAVLT).…”

Section: Discussionmentioning

confidence: 99%

White matter tractography in early psychosis: clinical and neurocognitive associations

Hatton

Lagopoulos

Hermens

et al. 2014

jpn

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“…Decreased FA in the left IFOF predicts worse neurocognitive performance both in never-medicated chronic schizophrenia [46] and in adolescents with earlyonset schizophrenia [47] , as well as predicting empathic impairments in patients with schizophrenia [48] . Other whitematter fiber tracts related to the PFC in schizophrenia include the anterior limb of the internal capsule, the medial portion of which includes the anterior thalamic radiation linking the thalamus and the PFC [49,50] , the genu of the corpus callosum linking the bilateral PFCs [51,52] , and deep white matter within the PFC [53] .…”

Section: Arcuate Fasciculusmentioning

confidence: 99%

“…Even though Brodmanndefined brain areas have their unique internal structure, such as the frontal pole (i.e. Brodmann area 10), functional subregions are also suggested due to the distinct anatomical and functional connectivity patterns [46] . Based on the cytoarchitecture, the distribution patterns of multireceptor, co-activation patterns, and anatomical and/or functional connectivity, each of the PFC regions (DLPFC, ventrolateral PFC, MPFC, OFC, and frontal pole) has been parcellated into subregions [76][77][78][79][80][81][82] .…”

Section: Fine-grained Parcellation Of the Pfcmentioning

confidence: 99%

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

et al. 2015

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Schizophrenia is hypothesized to arise from disrupted brain connectivity. This "dysconnectivity hypothesis" has generated interest in discovering whether there is anatomical and functional dysconnectivity between the prefrontal cortex (PFC) and other brain regions, and how this dysconnectivity is linked to the impaired cognitive functions and aberrant behaviors of schizophrenia. Critical advances in neuroimaging technologies, including diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), make it possible to explore these issues. DTI affords the possibility to explore anatomical connectivity in the human brain in vivo and fMRI can be used to make inferences about functional connections between brain regions. In this review, we present major advances in the understanding of PFC anatomical and functional dysconnectivity and their implications in schizophrenia. We then briefly discuss future prospects that need to be explored in order to move beyond simple mapping of connectivity changes to elucidate the neuronal mechanisms underlying schizophrenia.

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Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: A diffusion tensor study using TBSS

Cited by 90 publications

References 87 publications

Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls

Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls

White matter tractography in early psychosis: clinical and neurocognitive associations

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

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