Reduced volume of the left cerebellar lobule VIIb and its increased connectivity within the cerebellum predict more general psychopathology one year later via worse cognitive flexibility in children

Zhao, Gai; Zhang, Haibo; Ma, Leilei; Wang, Yanpei; Chen, Rui; Liu, Ningyu; Men, Weiwei; Tan, Shuping; Gao, Jia-Hong; Qin, Shaozheng; He, Yong; Dong, Qi; Tao, Sha

doi:10.1016/j.dcn.2023.101296

Cited by 3 publications

(1 citation statement)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each prioritized cognitive and motor task in the VWM-B can lead to increased activation of specific cerebral or cerebellar regions. According to recent studies, the VWM-B program activates critical cerebral (the left fusiform gyrus) and cerebellar (Crus II) regions [2,60] which are essential for various reading skills [60,[114][115][116][117][118][119][120][121]. Future studies can explore the possible association between the activation of cerebral and cerebellar regions induced by the VWM-B program and reading-related EFs.…”

Section: Discussionmentioning

confidence: 99%

Cognitive-Motor Training Improves Reading-Related Executive Functions: A Randomized Clinical Trial Study in Dyslexia

Ramezani,

Fawcett

2024

Brain Sciences

View full text Add to dashboard Cite

Children with developmental dyslexia (DD) often struggle with executive function difficulties which can continue into adulthood if not addressed. This double-blinded randomized clinical trial study evaluated the short-term effects of the Verbal Working Memory-Balance (VWM-B) program on reading-related executive functions, reading skills, and reading comprehension in Persian children with DD. The active control group [12 children with DD with a mean age of 9 years (SD = 0.90)] received training using the single-task VWM program, while the experiment group [15 children with DD with a mean age of 8 years (SD = 0.74)] received training with the dual-task VWM-B program. Both groups received fifteen training sessions, and assessments were conducted before and after the intervention. The groups were homogenized for possible confounders of age, gender, IQ level, and attention level. The study employed separate mixed ANOVA analyses to estimate the impact of training programs on various measured functions. Significant improvements were observed in the outcome measures of backward digit span, text comprehension, verbal fluency, Stroop color–word test and interference, and the reading subtests. Additionally, significant correlations were found between reading skills and backward digit span, text comprehension, verbal fluency, and Stroop variables. In conclusion, the dual-task VWM-B program was found to be more effective than the single-task VWM program in improving selective attention, cognitive inhibition, verbal working memory capacity, information processing speed, naming ability, and lexical access speed. These enhanced executive functions were associated with improved reading skills in children with DD.

show abstract

Section: Discussionmentioning

confidence: 99%

Cognitive-Motor Training Improves Reading-Related Executive Functions: A Randomized Clinical Trial Study in Dyslexia

Ramezani,

Fawcett

2024

Brain Sciences

View full text Add to dashboard Cite

show abstract

Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier

Yang,

Liu,

Chen

et al. 2024

MedComm

View full text Add to dashboard Cite

The cerebellum is crucial for both motor and nonmotor functions. Alzheimer's disease (AD), alongside other dementias such as vascular dementia (VaD), Lewy body dementia (DLB), and frontotemporal dementia (FTD), as well as other neurodegenerative diseases (NDs) like Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and spinocerebellar ataxias (SCA), are characterized by specific and non‐specific neurodegenerations in central nervous system. Previously, the cerebellum's significance in these conditions was underestimated. However, advancing research has elevated its profile as a critical node in disease pathology. We comprehensively review the existing evidence to elucidate the relationship between cerebellum and the aforementioned diseases. Our findings reveal a growing body of research unequivocally establishing a link between the cerebellum and AD, other forms of dementia, and other NDs, supported by clinical evidence, pathological and biochemical profiles, structural and functional neuroimaging data, and electrophysiological findings. By contrasting cerebellar observations with those from the cerebral cortex and hippocampus, we highlight the cerebellum's distinct role in the disease processes. Furthermore, we also explore the emerging therapeutic potential of targeting cerebellum for the treatment of these diseases. This review underscores the importance of the cerebellum in these diseases, offering new insights into the disease mechanisms and novel therapeutic strategies.

show abstract

Altered prefrontal and cerebellar parvalbumin neuron counts are associated with cognitive changes in male rats

King,

Maze,

Plakke

2024

Exp Brain Res

View full text Add to dashboard Cite

Reduced volume of the left cerebellar lobule VIIb and its increased connectivity within the cerebellum predict more general psychopathology one year later via worse cognitive flexibility in children

Cited by 3 publications

References 93 publications

Cognitive-Motor Training Improves Reading-Related Executive Functions: A Randomized Clinical Trial Study in Dyslexia

Cognitive-Motor Training Improves Reading-Related Executive Functions: A Randomized Clinical Trial Study in Dyslexia

Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier

Altered prefrontal and cerebellar parvalbumin neuron counts are associated with cognitive changes in male rats

Contact Info

Product

Resources

About