Reduced vitamin D levels are associated with autoimmune response in tuberculosis patients: Figure 1

Li, Wenli; Zhang, Rui; Zhang, Kuo; Song, Lihua; Hong, Ping; Zhang, Yuan; Xie, Jiehong; Wang, Lunan; Li, Jinming

doi:10.1136/annrheumdis-2011-201127

Cited by 7 publications

(2 citation statements)

References 7 publications

(7 reference statements)

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“…Increasing 25(OH)D serum levels in African American patients with SLE might be beneficial in maintaining telomere length and preventing cellular aging . Reduced serum 25(OH)D levels have also been found to be associated with the presence of autoimmune responses in tuberculosis patients showing a significant negative correlation between titres of ANA and serum levels of 25(OH)D …”

Section: Vitamin D Deficiency and Autoantibody Productionmentioning

confidence: 99%

Vitamin D, steroid hormones, and autoimmunity

Cutolo

Paolino

Sulli

et al. 2014

Annals of the New York Academy of Sciences

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The endogenous serum metabolite of vitamin D (calcitriol, 1,25(OH)2 D3 ) is considered a true steroid hormone (D hormone), and like glucocorticoids (GCs) and gonadal hormones, may exert several immunomodulatory activities. Serum vitamin D deficiency (25(OH) D), and therefore reduced 1,25(OH)2 D3 availability, is considered a risk factor for several chronic/inflammatory or autoimmune conditions, including infectious diseases, type 1 diabetes, multiple sclerosis, and especially autoimmune rheumatic diseases (ARD). In ARD in particular, 1,25(OH)2 D3 regulates both innate and adaptive immunity, potentiating the innate response (antimicrobial activity) but reducing adaptive immunity (antigen presentation, T and B cell activities). Regarding a possible synergism between vitamin D and GCs, several studies show that 1,25(OH)2 D3 has significant additive effects on dexamethasone-mediated inhibition of human lymphocyte and monocyte proliferation. Conversely, vitamin D deficiency seems to play a role in increasing autoantibody production by B cells, and seasonal vitamin D declines may trigger flares in ARD, as recently shown. Finally, 1,25(OH)2 D3 seems to reduce aromatase activity and limit the negative effects related to increased peripheral estrogen metabolism (cell proliferation, B cell overactivity).

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Section: Vitamin D Deficiency and Autoantibody Productionmentioning

confidence: 99%

Vitamin D, steroid hormones, and autoimmunity

Cutolo

Paolino

Sulli

et al. 2014

Annals of the New York Academy of Sciences

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“…Se determinaron los niveles de 25 (OH)D en los 87 pacientes (ANA +) y en 87 pacientes (ANA-), encontrando que aquellos con anticuerpos antinucleares positivos presentaban niveles significativamente disminuidos de vitamina D (31,3±15,1 vs. 38,1±14,6 nmol/l, p=0,003). Aunque la muestra se considera pequeña, es uno de los pocos estudios clínicos que evidencia el papel inmunomodulador de la vitamina D (63) .…”

Section: Ensayos Clínicosunclassified

Tuberculosis y vitamina D: una relación intrigante

Ramos

Salamanca-Montilla

Correa

et al. 2019

Rev.ACE

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La tuberculosis permanece como la enfermedad infecciosa que más muertes ha causado a lo largo de la historia de la existencia humana, sin poderse aún lograr su control. En años recientes ha emergido un cúmulo importante de evidencia clínica acerca de la función de la vitamina D (calcitriol o 1,25 hidroxivitamina D) en un papel que va más allá de la homeostasis del calcio. Su papel en el sistema inmunológico es muy interesante vinculando su déficit como un factor de riesgo contribuyente y así mismo fisiopatológico en un gran número de enfermedades autoinmunes e infecciosas. Dentro de éstas se destaca la tuberculosis, enfermedad endémica en nuestro país y en la cual el déficit de dicho compuesto (vitamina D) crea un factor de riesgo para desarrollar esta enfermedad en su forma activa. Presentamos una revisión detallada de los estudios que explican el papel de la vitamina D en la susceptibilidad para el desarrollo de tuberculosis y los resultados de los estudios clínicos de suplencia de la misma publicados a la fecha.

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