Reduced Risks of Neural Tube Defects and Orofacial Clefts With Higher Diet Quality

Derivation of Maternal Dietary Patterns Accounting for Regional Heterogeneity

“…As demonstrated with an application to the NBDPS, we learn that maternal diets that favour a high consumption of fruits and vegetables paired with a low consumption of land meats (chicken, beef) were associated with lower proportion of orofacial defects. These results are consistent with prior NBDPS studies that also showed a prudent diet or high diet quality score was related to lower proportion of orofacial cleft defects (Carmichael et al, 2012; Collier et al, 2009). Under the unsupervised RPC approach using this same data set in Stephenson, Sotres‐Alvarez, et al (2020), the global dietary patterns derived were different from those derived and discussed in the supervised approach discussed here.…”

Maternal Periconceptional Folic Acid Supplementation and the Risk of Non-Syndromic Oral Clefts in Offspring: A Population-Based Case-Control Study in Chengdu, China

“…Consistent with previous studies in some western [9][10][11][12][13][14][15][16][17] and Asian non-Chinese populations, 19,20 our results showed that maternal periconceptional FAS could reduce the risk of overall NsCL/P by approximately 60% regardless of the initiation timing. This preventive effect was observed for both NsCL and NsCLP.…”

Supervised Robust Profile Clustering

“…Applying this to the NBDPS maternal dietary information, we learn that diets that favor a high consumption of fruits and vegetables paired with a low consumption of land meats (chicken, beef) were associated with lower proportion of orofacial defects. These results are consistent with prior NBDPS studies that also showed a prudent diet or high diet quality score was related to lower proportion of orofacial cleft defects (Carmichael et al, 2012;Collier et al, 2009). The results from the supervised RPC model add to the previous studies by highlighting consumption patterns of a subset of foods that are commonly consumed across the United States.…”