Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements

Abstract

Use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD. Antioxidant supplements merit further study as agents for the primary prevention of AD.

Supplemental Use of Antioxidant Vitamins and Subsequent Risk of Cognitive Decline and Dementia

“…Contrary to the earlier fi ndings reported by Morris et al [13] and the most recent large population-based investigation by Zandi et al [5] , we failed to observe a statistically signifi cant association between antioxidant vitamin supplement use and subsequent risk of AD. Relative to the East Boston Study [13] , our CSHA cohort was larger and arguably more cognitively vulnerable at baseline.…”

Supplemental Use of Antioxidant Vitamins and Subsequent Risk of Cognitive Decline and Dementia

“…Contrary to the earlier fi ndings reported by Morris et al [13] and the most recent large population-based investigation by Zandi et al [5] , we failed to observe a statistically signifi cant association between antioxidant vitamin supplement use and subsequent risk of AD. Relative to the East Boston Study [13] , our CSHA cohort was larger and arguably more cognitively vulnerable at baseline.…”

Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline

“…Our results are generally consistent with earlier reports from population-based studies, 10,11,17,26 but not all, 14,27,28 that provided much of the evidence for a protective effect of both vitamin E and C supplements against AD and cognitive decline. In contrast to other studies, vitamin supplement use taken alone was also associated with reduced risks.…”

Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study

“…Although cognitive function was assessed using cognitive tests in these studies, the incidence of dementia or MCI was not investigated. Associations between vitamin C intake or supplements and risk for dementia or cognitive decline have been investigated in several large population studies [4][5][6][7]. In the Rotterdam study, partly similar to our results, higher intake of antioxidant supplements (vitamins C and E) tended to be associated with lower risk of AD in APOE ε4-positive participants [4].…”

Supplemental Use of Antioxidant Vitamins and Subsequent Risk of Cognitive Decline and Dementia

“…Contrary to the earlier fi ndings reported by Morris et al [13] and the most recent large population-based investigation by Zandi et al [5] , we failed to observe a statistically signifi cant association between antioxidant vitamin supplement use and subsequent risk of AD. Relative to the East Boston Study [13] , our CSHA cohort was larger and arguably more cognitively vulnerable at baseline.…”

Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline

“…Our results are generally consistent with earlier reports from population-based studies, 10,11,17,26 but not all, 14,27,28 that provided much of the evidence for a protective effect of both vitamin E and C supplements against AD and cognitive decline. In contrast to other studies, vitamin supplement use taken alone was also associated with reduced risks.…”

Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study

“…Although cognitive function was assessed using cognitive tests in these studies, the incidence of dementia or MCI was not investigated. Associations between vitamin C intake or supplements and risk for dementia or cognitive decline have been investigated in several large population studies [4][5][6][7]. In the Rotterdam study, partly similar to our results, higher intake of antioxidant supplements (vitamins C and E) tended to be associated with lower risk of AD in APOE ε4-positive participants [4].…”

Supplemental Use of Antioxidant Vitamins and Subsequent Risk of Cognitive Decline and Dementia

“…Contrary to the earlier fi ndings reported by Morris et al [13] and the most recent large population-based investigation by Zandi et al [5] , we failed to observe a statistically signifi cant association between antioxidant vitamin supplement use and subsequent risk of AD. Relative to the East Boston Study [13] , our CSHA cohort was larger and arguably more cognitively vulnerable at baseline.…”

Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline

“…Our results are generally consistent with earlier reports from population-based studies, 10,11,17,26 but not all, 14,27,28 that provided much of the evidence for a protective effect of both vitamin E and C supplements against AD and cognitive decline. In contrast to other studies, vitamin supplement use taken alone was also associated with reduced risks.…”

Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study

“…Although cognitive function was assessed using cognitive tests in these studies, the incidence of dementia or MCI was not investigated. Associations between vitamin C intake or supplements and risk for dementia or cognitive decline have been investigated in several large population studies [4][5][6][7]. In the Rotterdam study, partly similar to our results, higher intake of antioxidant supplements (vitamins C and E) tended to be associated with lower risk of AD in APOE ε4-positive participants [4].…”