Reduced quality of life in patients with chronic hepatitis C: effects of interferon treatment

Bianchi, Giampaolo; Loguercio, C.; Sgarbi, D.; Abbiati, R.; Chen, C.H.; Pierro, M. Di; Disalvo, D.; Natale, S.; Marchesini, Giulio

doi:10.1016/s1590-8658(00)80260-1

Cited by 48 publications

(27 citation statements)

References 26 publications

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“…In these instances, however, 16 publications (42.1 %) gave preference to the SF-36 while only one article (2.6 %) (indirectly) rated the NHP higher. In this study Bianchi et al (2000) report that the NHP registered group differences in health-related quality of life between hepatological patients who received interferon treatment and those who did not; however, the differences were not significant when the SF-36 was used [10]. This one instance of a preference for the NHP is in contrast to a large body of publications that drew the opposite conclusion.…”

Section: Nhp and Sf-36mentioning

confidence: 71%

Which instrument is more suitable to assess health-related quality of life: Nottingham Health Profile or Short-Form-36?

Jagsch

Pils²

2006

Wien Med Wochenschr

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Section: Nhp and Sf-36mentioning

confidence: 71%

Which instrument is more suitable to assess health-related quality of life: Nottingham Health Profile or Short-Form-36?

Jagsch

Pils²

2006

Wien Med Wochenschr

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“…So, treatment for HCV is lengthy, rigorous, and associated with side effects that are difficult to manage [7].…”

Section: Introductionmentioning

confidence: 99%

Liver enzymes and psychological well-being response to aerobic exercise training in patients with chronic hepatitis C

El-Kader

Al-Jiffri²,

Al-Shreef³

2014

Afr H. Sci.

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Background: Chronic hepatitis C (CHC) is a medical condition that has broad implications for a person's physical and psychological health. Objective: The aim of this study was to detect changes in liver enzymes and psychological well-being in response to aerobic exercise training in patients with CHC. Material and Methods: Fifty CHC patients were included in two equal groups. The first group (A) received aerobic exercise training in addition to their regular medical treatment. The second group (B) received no training and only has their regular medical treatment. The program consisted of three sessions per week for three months. Results: There was a significant decrease in mean values of Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Gamma -Glutamyltransferase (GGT) , Beck Depression Inventory (BDI ) & Profile of Mood States(POMS) and increase in Rosenberg Self-Esteem Scale (RSES) in group (A) after treatments, but the changes in group (B) were not significant. Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study. Conclusion: Aerobic exercise training improves hepatic enzymes and psychological well-being in patients with chronic hepatitis C.

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“…(15)(16). To date, the causal factors of a reduced HRQoL in such patients are poorly understood, even though psychological and social impact of Hepatitis C Virus (HCV) infection diagnosis, as well as HCV itself and interferon treatment, seem to play a crucial role (17)(18)(19). On the other hand, neither the stage of the liver disease nor the viral load nor the presence of extrahepatic manifestations seem to influence the HRQoL (20).…”

mentioning

confidence: 99%

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

Racciatti

Gorgoretti

Sepede

et al. 2011

Int J Immunopathol Pharmacol

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Severe fatigue and a significantly reduced health-related quality of life (HRQoL) have been described in patients with chronic fatigue syndrome (CFS) in comparison with patients affected by chronic hepatitis C (CHC) and other chronic medical conditions. We examined 39 CFS and 49 CHC patients to explore whether fatigue and a poor HRQoL represent a greater medical and social problem in CFS than in CHe. The severity of fatigue and the HRQoL were assessed using the Fatigue Impact Scale (FIS) and the Health Status Questionnaire Short Form-36 (SF-36), respectively. The statistical analysis showed both a higher score offatigue and a lower HRQoL in CFS than in CHC patients. Furthermore, in CUC patients the FIS evaluation showed a significantly reduced score of the psychosocial domain in comparison with the other domains. Multivariate linear regression analysis revealed female gender as the most important positive variable in chronic hepatitis C patients for total score of FIS. In conclusion, CFS was associated with a severe and disabling fatigue and an impaired HRQOL. In particular, both fatigue and all aspects of HRQOL perceived by CFS patients were significantly impaired compared to CHC patients. Consequently, management of fatigue should be considered a priority in order to improve HRQOL in CFS patients. In CHC patients the impact of fatigue on HRQoL was less significant than in CFS patients, even though the FIS evaluation showed a significant impairment of the psychosocial domain.

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Reduced quality of life in patients with chronic hepatitis C: effects of interferon treatment

Cited by 48 publications

References 26 publications

Which instrument is more suitable to assess health-related quality of life: Nottingham Health Profile or Short-Form-36?

Which instrument is more suitable to assess health-related quality of life: Nottingham Health Profile or Short-Form-36?

Liver enzymes and psychological well-being response to aerobic exercise training in patients with chronic hepatitis C

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

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